Prolonged abstinence from developmental cocaine exposure dysregulates BDNF and its signaling network in the medial prefrontal cortex of adult rats

The International Journal of Neuropsychopharmacology
Giuseppe GiannottiFabio Fumagalli

Abstract

Although evidence exists that chronic cocaine exposure during adulthood is associated with changes in BDNF expression, whether and how cocaine exposure during adolescence modulates BDNF is still unknown. To address this issue, we exposed rats to repeated cocaine injections from post-natal day (PD) 28 to PD 42, a period that roughly approximates adolescence in humans, and we carried out a detailed analysis of the BDNF system in the medial prefrontal cortex (mPFC) of rats sacrificed 3 d (PD 45) and 48 d (PD 90) after the last cocaine treatment. We found that developmental exposure to cocaine altered transcriptional and translational mechanisms governing neurotrophin expression. Total BDNF mRNA levels, in fact, were enhanced in the mPFC of PD 90 rats exposed to cocaine in adolescence, an effect sustained by changes in BDNF exon IV through the transcription factors CaRF and NF-kB. While a profound reduction of specific BDNF-related miRNAs (let7d, miR124 and miR132) may contribute to explaining the increased proBDNF levels, the up-regulation of the extracellular proteases tPA is indicative of increased processing leading to higher levels of released mBDNF. These changes were associated with increased activation of the trkB-Akt pathw...Continue Reading

References

May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
May 7, 2003·Neuroscience and Biobehavioral Reviews·Susan L Andersen
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lin LuYavin Shaham
Jul 15, 2004·Annals of the New York Academy of Sciences·Ann E KelleyCharles F Landry
Jun 1, 2005·Brain Research Bulletin·Flemming AndersenUNKNOWN DaNeX Study Group
Jan 21, 2006·Brain Research·Małgorzata FilipMarta Dziedzicka-Wasylewska
Jul 27, 2007·The European Journal of Neuroscience·William J BerglindJacqueline F McGinty
Oct 5, 2007·Biochimica Et Biophysica Acta·Lukasz SwiechJacek Jaworski
Nov 16, 2007·The European Journal of Neuroscience·Fabio FumagalliMarco Andrea Riva
Jun 10, 2008·Behavioural Brain Research·Sabine ChourbajiPeter Gass
Aug 9, 2008·Developmental Review : DR·B J CaseyAdriana Galvan
Jan 13, 2009·Pharmacology, Biochemistry, and Behavior·Monique ErnstSusan L Andersen
Feb 19, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Fabio FumagalliMarco Andrea Riva
Mar 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William J BerglindJacqueline F McGinty
Jul 29, 2009·Behavioral Neuroscience·Robert C TwiningPatricia S Grigson
Aug 20, 2009·Experimental Brain Research·Clive R BramhamKarin Wibrand
Aug 26, 2009·Molecular and Cellular Neurosciences·Vijay Chandrasekar, Jean-Luc Dreyer
Sep 8, 2009·Brain Research·Jacqueline F McGintyWilliam J Berglind
Dec 8, 2009·Trends in Neurosciences·Charles A Hoeffer, Eric Klann
May 12, 2010·Journal of Neurochemistry·Alessandro BarbonSergio Barlati
Sep 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ghazaleh Sadri-VakiliJang-Ho J Cha
Sep 24, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xi WangLin Lu
Oct 15, 2010·The International Journal of Neuropsychopharmacology·Matthew C HearingJacqueline F McGinty
Jan 21, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Timothy W WhitfieldJacqueline F McGinty
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Priit PruunsildTõnis Timmusk
May 19, 2011·Psychopharmacology·Lucia CaffinoFabio Fumagalli
Nov 21, 2012·The International Journal of Neuropsychopharmacology·Fabio FumagalliLuigi Cervo

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Citations

Dec 27, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lucia CaffinoCristiano Chiamulera
Nov 26, 2015·Neuroscience and Biobehavioral Reviews·Juan F Codocedo, Nibaldo C Inestrosa
Mar 1, 2016·Neurobiology of Disease·Elizabeth G PittsShannon L Gourley
May 26, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Lucia CaffinoFabio Fumagalli
Jul 15, 2015·Journal of Molecular Neuroscience : MN·Yaarit Simchon TenenbaumMoshe Rehavi
Oct 30, 2016·Life Sciences·Mahendra KashyapPradeep Tyagi
Nov 1, 2016·Molecular Neurobiology·Lucia CaffinoFabio Fumagalli
Jun 12, 2018·Addiction Biology·Ana-Clara BobadillaPeter W Kalivas
Jan 31, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Lucia CaffinoFabio Fumagalli
Dec 16, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hannah M CatesEric J Nestler
Jul 25, 2021·International Journal of Molecular Sciences·Lucia CaffinoFabio Fumagalli

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