Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors.

Proceedings of the National Academy of Sciences of the United States of America
Miho TerunumaAndrés Couve

Abstract

Slow and persistent synaptic inhibition is mediated by metabotropic GABAB receptors (GABABRs). GABABRs are responsible for the modulation of neurotransmitter release from presynaptic terminals and for hyperpolarization at postsynaptic sites. Postsynaptic GABABRs are predominantly found on dendritic spines, adjacent to excitatory synapses, but the control of their plasma membrane availability is still controversial. Here, we explore the role of glutamate receptor activation in regulating the function and surface availability of GABABRs in central neurons. We demonstrate that prolonged activation of NMDA receptors (NMDA-Rs) leads to endocytosis, a diversion from a recycling route, and subsequent lysosomal degradation of GABABRs. These sorting events are paralleled by a reduction in GABABR-dependent activation of inwardly rectifying K+ channel currents. Postendocytic sorting is critically dependent on phosphorylation of serine 783 (S783) within the GABABR2 subunit, an established substrate of AMP-dependent protein kinase (AMPK). NMDA-R activation leads to a rapid increase in phosphorylation of S783, followed by a slower dephosphorylation, which results from the activity of AMPK and protein phosphatase 2A, respectively. Agonist act...Continue Reading

References

Feb 14, 1991·Nature·C H DaviesG L Collingridge
Jan 1, 1994·International Review of Neurobiology·D D Mott, D V Lewis
Feb 15, 2001·The Journal of Comparative Neurology·Y GoncharA Burkhalter
Apr 3, 2001·Nature Reviews. Neuroscience·S J Moss, T G Smart
Nov 17, 2001·The Journal of Biological Chemistry·Béatrice DutheyLaurent Prézeau
Feb 8, 2002·Molecular Neurobiology·R Sattler, M Tymianski
Feb 14, 2002·Drug and Alcohol Dependence·Michael S CousinsHarriet de Wit
Feb 19, 2002·The European Journal of Neuroscience·Akos KulikRyuichi Shigemoto
Jul 26, 2003·The EMBO Journal·Julie PerroyMichel Bouvier
Nov 19, 2003·The European Journal of Neuroscience·Andrea StraessleJean-Marc Fritschy
Jan 7, 2004·The Journal of Biological Chemistry·Benjamin P FairfaxAndrés Couve
Jan 20, 2004·Trends in Biochemical Sciences·David Carling
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Christopher M TanLee E Limbird
Jul 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martin GassmannBernhard Bettler
Jul 23, 2004·Physiological Reviews·Bernhard BettlerMartin Gassmann
Sep 29, 2004·Biochemical Pharmacology·Andrés CouveMenelas N Pangalos
Sep 29, 2004·Biochemical Pharmacology·Seb J ThuaultAndrew R Calver
Nov 20, 2004·Nature Reviews. Neuroscience·Graham L CollingridgeYu Tian Wang
Mar 31, 2005·Molecular and Cellular Neurosciences·Sophie RestituitoStephen J Moss
Dec 20, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ryoko YumotoMikihisa Takano
Aug 15, 2006·Current Opinion in Cell Biology·Matthew C JonesJim C Norman
Nov 1, 2006·Biochimica Et Biophysica Acta·Chunmin DongGuangyu Wu
Apr 5, 2007·Nature Protocols·Min Jiang, Gong Chen
Jul 24, 2007·Neuropharmacology·Bo-Shiun Chen, Katherine W Roche
Sep 25, 2008·The Journal of Biological Chemistry·Megan E WilkinsTrevor G Smart
Oct 25, 2008·Molecular and Cellular Neurosciences·Thomas GramppDietmar Benke
Mar 12, 2009·The Journal of Biological Chemistry·Omar A RamírezAndrés Couve
Jul 29, 2009·European Journal of Immunology·Erick RiquelmeAlexis M Kalergis
Aug 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne-Marie M OswaldAlex D Reyes
Apr 20, 2010·Neuron·Jason R Chalifoux, Adam G Carter

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Citations

Feb 7, 2013·Neurochemistry International·Susan C Buckingham, Stefanie Robel
Sep 26, 2013·Trends in Endocrinology and Metabolism : TEM·Owen Chan, Robert Sherwin
May 19, 2012·Nature Reviews. Neuroscience·Martin Gassmann, Bernhard Bettler
Jul 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Saad HannanTrevor G Smart
Jul 5, 2011·The Journal of Biological Chemistry·Saad HannanTrevor G Smart
Aug 23, 2011·Annual Review of Pharmacology and Toxicology·Hanns Ulrich ZeilhoferGonzalo E Yevenes
Apr 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Svetlana BurmakinaQing R Fan
May 26, 2012·Cellular and Molecular Life Sciences : CMLS·Tz-Chuen JuYijuang Chern
Jan 28, 2016·Neuroscience and Biobehavioral Reviews·Chelcie F Heaney, Jefferson W Kinney
Nov 4, 2015·Neuro-oncology·Terri S ArmstrongAndrew D Norden
Dec 28, 2010·Neuroscience Letters·Xiu-Li WangYue-Xian Guo
Dec 2, 2015·Frontiers in Neural Circuits·Roxana A Stefanescu, Susan E Shore
Jun 1, 2011·Journal of Neurochemistry·Antero SalminenMikko Hiltunen
Jun 19, 2012·The Biochemical Journal·David CarlingMatthew J Sanders
Sep 28, 2014·Neuropharmacology·Miho TerunumaStephen J Moss
Apr 7, 2015·Neuropharmacology·Ezequiel Marron Fernandez de VelascoKevin Wickman
Apr 29, 2015·Frontiers in Cellular Neuroscience·Sriharsha Kantamneni
Jun 12, 2013·Neuropharmacology·E R WorkmanKimberly F Raab-Graham
Dec 8, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lei LiuAlexei Morozov
Jan 24, 2018·Synapse·Adeline Orts-Del'Immagine, Jason R Pugh
Dec 14, 2018·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Miho Terunuma
Jan 16, 2014·The Journal of Biological Chemistry·Sriharsha KantamneniJeremy M Henley
Jun 5, 2014·Journal of Cell Science·José I ValenzuelaAndrés Couve
Feb 23, 2020·Journal of Neurochemistry·Mohammad I K HamadEckart Förster
Mar 25, 2019·Nature Communications·Margarita C DinamarcaBernhard Bettler
Nov 14, 2019·Frontiers in Pharmacology·Ilaria Dal PràAnna Chiarini
Apr 7, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaoling HeDeqiang Huang
Nov 2, 2012·Journal of Neuroscience Research·E D GaierR E Mains

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