Prolonged administration enhances the renoprotective effect of pentoxifylline via anti-inflammatory activity in streptozotocin-induced diabetic nephropathy.

Inflammation
Kum Hyun HanDae Ryong Cha

Abstract

The beneficial effects of pentoxifylline (PTX), which has an anti-inflammatory and renoprotective effect in diabetic nephropathy, are not completely understood. This study investigates whether prolonged administration of PTX (40 mg/kg, per oral) is effective in streptozotocin-induced diabetic nephropathy. The amount of urinary protein was higher in the diabetic rats than in the control rats. The amount remained unchanged after 4 weeks and decreased after 8 weeks of PTX treatment. Accumulation of monocyte chemoattractant peptide-1 (MCP-1) and mouse monoclonal anti-monocyte/macrophage antibody (ED-1) positive cells was higher in untreated diabetic rats than in the control rats. PTX administration ameliorated the urinary MCP-1 excretion and interstitial infiltration of ED-1 positive cells at 4 weeks. Further, in diabetic rats, administration of PTX for 4 weeks inhibited the renal inflammatory reaction, and when administration for 8 weeks, it prevented proteinuria. These findings support the hypothesis that prolonged administration enhances the protective effects of PTX.

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Citations

Apr 11, 2013·International Urology and Nephrology·Vahideh YavariMaryam Pakfetrat
Jan 10, 2016·Current Hypertension Reports·Shelly Bhanot, David J Leehey
Dec 6, 2011·Transplantation Reviews·María José SolerJulio Pascual
Jun 19, 2012·The Korean Journal of Internal Medicine·Shin-Wook Kang
Jun 15, 2015·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zeng-Mei AnTao Qin
Aug 18, 2010·Biochimica Et Biophysica Acta·Giuseppe M CampoSalvatore Campo
Apr 28, 2010·Nature Reviews. Nephrology·Vivette D'Agati, Ann Marie Schmidt
Feb 18, 2012·The Cochrane Database of Systematic Reviews·Dan ShanGuan J Liu

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