Dec 1, 1977

Prolonged administration of bleomycin without clinical toxicity. Therapy with 2,700 units over four years

Chest
J E Kurnick

Abstract

A 26-year-old white man with stage 4-B Hodgkin's disease resistant to conventional chemotherapy obtained complete remission with administration of bleomycin. Maintenance of this remission required continued therapy with bleomycin. The patient received a total of 2,700 units of bleomycin over a 51-month period without signs or symptoms of pulmonary toxicity. Serial studies of pulmonary function have shown a stable forced vital capacity and minimally decreased total lung volume and pulmonary diffusing capacity. This case demonstrates the ability of a patient to tolerate massive cumulative doses ob bleomycin over a protracted period without severe loss of pulmonary function.

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Mentioned in this Paper

Remission, Spontaneous
Lung
Drug-Induced Liver Injury
Reflex, Abnormal
Hodgkin Lymphoma, Lymphocyte Depletion
Respiratory Function Tests

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