PMID: 7543761May 1, 1995Paper

Prolonged alteration of vasoconstrictor and vasodilator responses in rat knee joints by adjuvant monoarthritis

Experimental Physiology
J J McDougallW R Ferrell

Abstract

Both neurogenic influences and the regulatory neuropeptide substance P (SP) have been implicated in the development of joint inflammation. Using the laser Doppler perfusion imaging technique to quantify relative changes in joint blood flow, the effects of nerve stimulation and topical SP application were examined in normal and chronically inflamed rat knee joints. Synovial inflammation was induced by unilateral intra-articular injection of Freund's complete adjuvant and experiments were carried out 1 week and 3 weeks later. Normal knees showed a frequency-dependent vasoconstriction in response to saphenous nerve stimulation over the range of 5-30 Hz and a dose-dependent vasodilation in response to SP administration. These vasoactive responses were completely abolished in the chronically inflamed knee joint, the abolition persisting throughout the investigation. Since articular cartilage is critically dependent on synovial fluid formation for its nutrition, loss of neurovascular control of the synovial microcirculation could contribute to the degenerative changes that commonly accompany chronic inflammatory joint diseases.

Citations

Nov 1, 1996·The Histochemical Journal·D A WalshT P Fan
Apr 6, 2004·The Journal of Physiology·Colin G EganWilliam R Ferrell
Dec 15, 2015·CNS Neuroscience & Therapeutics·Milind M MuleyJason J McDougall
Dec 9, 2008·The Medical Clinics of North America·David J HunterFrancis J Keefe
Aug 9, 2008·Rheumatic Diseases Clinics of North America·David J HunterFrancis J Keefe
May 31, 2015·Current Osteoporosis Reports·Eugene KrustevJason J McDougall
Oct 17, 2012·PloS One·Kristina Ängeby MöllerOdd-Geir Berge
Aug 25, 2016·Journal of Biomedical Science·Wei JiangWei Luo
Jul 24, 2001·Arthritis and Rheumatism·P I MappD R Blake
Dec 13, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jason J McDougallChelsea M McDougall
Jun 14, 2006·Pflügers Archiv : European journal of physiology·Hamid Najafipour, Saeid Niazmand
Aug 1, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Benjamin AndruskiJason J McDougall
Feb 28, 2009·Arthritis and Rheumatism·Jason J McDougallNathalie Vergnolle
Mar 10, 1999·The American Journal of Physiology·J J McDougallR C Bray
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J J McDougall
Nov 15, 2020·Journal of Neuroscience Methods·Cynthia AbboudMarc Landry
Dec 9, 2020·British Journal of Pharmacology·Meagan McKenna, Jason J McDougall

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