Abstract
100 patients with a modified Ivy bleeding time longer than 10 min in the presence of more than 80 x 10(9)/l blood platelets were studied retrospectively. 72 patients had repeated bleeding times between 10 and 20 min or one or more measurements exceeding 20 min, and were considered to have an unquestionable platelet dysfunction. 39 (54%) of these 72 patients were receiving large doses of antibiotics. Nearly one half of the patients on antibiotics had a bleeding tendency, but most of these patients had additional features that may have interfered with platelet function, or a coagulation defect. In the remaining 33 patients, the prolonged bleeding time was associated with von Willebrand's disease, liver disease, leukaemia/myeloproliferative disease, paraproteinaemia or aspirin ingestion. High doses of penicillin seem to be the most common cause of qualitative platelet disorders in general hospital practice.
References
Nov 13, 1976·Lancet·K AndrassyH Storch
Sep 11, 1975·The New England Journal of Medicine·H J Weiss
Aug 1, 1977·Thrombosis Research·H Johnsson, P M Niklasson
Nov 1, 1977·American Journal of Surgery·D R HaburchakE D Everett
Dec 19, 1970·Lancet·P D McClureD Crozier
Jul 9, 1966·Lancet·P A CastaldiJ H Stewart
May 23, 1970·Lancet·A LurieB Goldberg
Aug 8, 1974·The New England Journal of Medicine·C H BrownC P Alfrey
Jul 27, 1972·The New England Journal of Medicine·L A Harker, S J Slichter
Jan 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·J P CazenaveJ F Mustard
Sep 1, 1970·Journal of Clinical Pathology·J R O'BrienE Clark
Feb 1, 1980·The Journal of Clinical Investigation·S J ShattilJ Turnbull
Sep 1, 1961·American Journal of Clinical Pathology·R R PROCTOR, S I RAPAPORT
Dec 1, 1950·Journal of Applied Physiology·G BRECHER, E P CRONKITE
Citations
Nov 1, 1990·European Journal of Haematology·J FornellsJ Felez
Aug 1, 1983·Scandinavian Journal of Haematology·F WisløffH C Godal
Sep 21, 2004·Journal of the Royal Army Medical Corps·J Krysa-ClarkT A Waterworth
Jan 3, 1991·The New England Journal of Medicine·J N George, S J Shattil
Jan 1, 1985·Scandinavian Journal of Thoracic and Cardiovascular Surgery·J Pillgram-LarsenG Semb
Apr 28, 2007·The Annals of Thoracic Surgery·Victor A FerrarisSimon Body