Prolonged central sensory conduction time in patients with chronic arsenic exposure

Journal of the Neurological Sciences
Hitoshi MochizukiMasamitsu Nakazato

Abstract

Many patients from Toroku, Japan, who have chronic arsenic exposure demonstrate whole-body sensory disturbance that is slightly more pronounced in the extremities. Although previous research in this population showed a mild peripheral neuropathy, it is unknown whether these patients have central nervous system impairment. To investigate the lesion sites underlying sensory disturbance related to chronic arsenic poisoning, we analyzed somatosensory evoked potentials (SEP). Clinical features, nerve conduction study results, and median and/or tibial SEP were analyzed in patients with chronic arsenic exposure (total, 13 patients; median & tibial, 4; median, 5; tibial, 4) retrospectively. The SEP findings in patients were compared with those in normal controls. The median SEP results indicated a conduction delay between the proximal brachial plexus and the primary sensory cortex, and tibial SEP findings indicated a delay between the dorsal gray matter of the lumbosacral cord and the primary sensory cortex. This is the first study to identify an impairment of the central somatosensory pathway in patients with chronic arsenic exposure. Sensory disturbance in these patients is related not only to peripheral neuropathy but also to impair...Continue Reading

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Citations

Apr 25, 2019·Environmental Health and Preventive Medicine·Hitoshi MochizukiYoshiki Kuroda
Jul 25, 2019·International Journal of Molecular Sciences·Hitoshi Mochizuki
Jul 6, 2018·Archives of Environmental Contamination and Toxicology·Nobuyuki IshiiMasamitsu Nakazato
Aug 11, 2020·Biological Trace Element Research·Baiming JinKewei Wang
Apr 17, 2021·Journal of Occupational Medicine and Toxicology·Magdalena KoszewiczSlawomir Budrewicz
Oct 6, 2021·Human & Experimental Toxicology·Macario Martínez-CastilloAraceli Hernández-Zavala

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