Prolonged childhood Cushing's syndrome secondary to intralesional triamcinolone acetonide

Annals of Tropical Paediatrics
S TeelucksinghP Arthur

Abstract

Intralesional corticosteroids have been used in the treatment of hypertrophic keloid scars for over 40 years. The few complications documented have mostly been local skin changes, viz depigmentation and cutaneous atrophy. Cushing's syndrome following intralesional injection is rare and usually self-limiting following cessation of therapy. This report describes a 9-year-old girl who developed Cushing's syndrome 2-3 weeks after a single treatment with 40 mg triamcinolone acetonide injected into keloids. Features of Cushing's syndrome and a suppressed hypothalamic-pituitary axis were present up to 9 months later. Three years after glucocorticoid injections, features of Cushing's syndrome had largely disappeared. Dosages of intralesional steroids normally recommended for adults are inappropriate for children.

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Citations

Dec 5, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michelle Ferdinand Liu, Myron Yencha
Jun 2, 2006·Journal of Paediatrics and Child Health·Rubina Hameed, Margaret R Zacharin
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Jan 1, 2008·Indian Journal of Dermatology·Selahattin KatarAhmet Yaramiş
Feb 18, 2006·Journal of Endocrinological Investigation·P IglesiasJ J Díez
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Feb 27, 2010·European Journal of Pediatrics·Martijn J J Finken, Dick Mul
Oct 6, 2004·Pediatric Dermatology·Zeynep SiklarYildiz Dallar
Aug 1, 2018·Pediatric Surgery International·Akinori SekiokaNaoto Urushihara
Jul 25, 2008·The Journal of Craniofacial Surgery·Brian BermanIsaac S Jones
Jan 13, 2006·Plastic and Reconstructive Surgery·Ali Al-AttarSteven P Davison
Apr 3, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Alev OzonNurgün Kandemir
Jun 14, 2005·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Steven KrakowkaGordon Allan
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Apr 27, 2005·Endocrinology and Metabolism Clinics of North America·Rachel L Hopkins, Matthew C Leinung

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