PMID: 16518289Mar 7, 2006Paper

Prolonged cholestasis associated with short-term use of celecoxib

Gastroentérologie Clinique Et Biologique
Patrick ChamouardRaoul Poupon

Abstract

Drug-induced liver injury due to celecoxib, a first generation Cox-2 inhibitor, has been rarely reported. We describe one case of severe and prolonged cholestasis after treatment with celecoxib for 12 days in a young woman with no evidence of other causes of liver disease or allergy. Jaundice lasted for 3 months, pruritus and abnormal liver biochemistry persisted for 18 months after stopping the drug. Liver biopsy specimens showed a cholestatic pattern of liver injury with only minimal mononuclear infiltrate in the portal tracts. This case report supports the notion that celecoxib may cause bland, long term cholestasis.

References

Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C DegottJ P Benhamou
Jul 7, 2001·BMJ : British Medical Journal·J P O'Beirne, S R Cairns
Nov 28, 2002·The Annals of Pharmacotherapy·Antonio GriecoGiovanni Gasbarrini

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Citations

Jul 19, 2013·Case Reports in Medicine·Suresh Kumar NayuduBhavna Balar
Mar 8, 2008·British Journal of Clinical Pharmacology·James H TabibianDavid M Kaufman
Sep 30, 2014·Critical Reviews in Toxicology·Rachel P L van SwelmFrans G M Russel
Oct 21, 2016·Expert Opinion on Drug Safety·Fernando BessoneRaúl J Andrade
Aug 11, 2017·Journal of Clinical Gastroenterology·Pavan K MukthinuthalapatiMarwan Ghabril

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