PMID: 8602670Feb 1, 1996Paper

Prolonged d-tubocurarine infusion and/or immobilization cause upregulation of acetylcholine receptors and hyperkalemia to succinylcholine in rats

Anesthesiology
P Yanez, J A Martyn

Abstract

Hyperkalemic cardiac arrest after the administration of succinylcholine (SCh) to critically ill intensive care patients has been attributed to changes in the acetylcholine receptors (AChRs) at the muscle membrane. The current study attempts to characterize the contributory roles of chronic administration of nondepolarizing muscle relaxants typified by d-tubocurarine (dTC) and/or of immobilization on AChR upregulation and the relationship of these AChR changes to SCh-induced hyperkalemia. Rats received chronic subparalytic infusion of saline or dTC for 28 days via subcutaneous osmotic pumps inserted while they were under anesthesia. Approximately half of the saline- or dTC-treated rats underwent bilateral hind-limb immobilization with plaster casts for the same duration as the infusion. After 4 weeks, the osmotic pumps were removed, and 24-48 h later, the blood potassium concentrations were measured at baseline and at 1, 3, 5, 7, and 10 min after SCh (3 mg/kg). At the end of this period, the gastrocnemius muscle was excised for quantitation of AChR number using (125)I-alpha-bungarotoxin. At 28 days, the weight gain in mobile animals receiving saline or dTC infusion did not differ, nor did that in immobilized animals receiving sa...Continue Reading

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Citations

Jan 22, 2002·Acta anaesthesiologica Belgica·G Cammu
Aug 1, 1997·Natural Product Reports·K W Bentley
Jul 20, 2006·International Anesthesiology Clinics·J A Jeevendra MartynHong Seuk Yang
Jul 6, 2012·Anesthesia and Analgesia·Antonia BlaniéBernard Vigué
Jan 5, 2014·Canadian Journal of Physiology and Pharmacology·Mohammed A S KhanJ A Jeevendra Martyn
Oct 16, 2015·Molecular Medicine Reports·Hong WangShi-Tong Li
Aug 29, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·F MégretA Ouattara
Jul 19, 2005·Muscle & Nerve·Mary C TherouxRobert E Akins
Feb 14, 2014·Annals of Intensive Care·Eric DieyeJean-Marie Conil
Nov 26, 2009·Anesthesiology·Gerald A Gronert
Oct 5, 2006·Current Opinion in Anaesthesiology·Anis S Baraka, Maya I Jalbout

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