PMID: 9523847Apr 2, 1998Paper

Prolonged decreases in plasma nitrate levels at early postoperative phase after hepato-pancreato-biliary surgery

The Journal of Laboratory and Clinical Medicine
S SatoiH Takahashi

Abstract

Nitric oxide (.NO) is known to influence circulatory, neural, immunologic, and metabolic alterations. To evaluate the clinical significance of .NO production under surgical stress, serial measurements of plasma nitrite plus nitrate levels were performed in 45 surgical patients. Group A included 19 patients who underwent major surgery with uneventful postoperative courses. Group B included 18 patients who underwent laparoscopic cholecystectomy. Group C included 8 patients whose surgery was complicated by intra-abdominal abscesses. Eight healthy volunteers served as controls. Plasma nitrate levels were determined with a redox chemiluminescence .NO analyzer and coincided with measurements made by high-performance liquid chromatography (r = 0.868, p < 0.0001, 58 samples). During laparotomy, arterial nitrate levels correlated well with peripheral, portal, and hepatic venous nitrate levels (r = 0.966, 0.938, and 0.949, respectively; p < 0.0001). A significant decrease in nitrate from preoperative levels in groups A (postoperative day (POD) 1 and 3; p < 0.0005) and B (POD 1, p < 0.0001) was observed; nitrate levels in group C did not decrease for 14 days after surgery. Plasma nitrate levels in groups A and B were significantly differe...Continue Reading

References

Sep 11, 1975·Journal of Agricultural and Food Chemistry·J W White
Nov 1, 1991·Annals of Surgery·J B OchoaA B Peitzman
Sep 15, 1989·Biochemical and Biophysical Research Communications·C D LeafS R Tannenbaum
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·L C GreenS R Tannenbaum
Nov 1, 1995·The Journal of Trauma·R L GamelliZ Radisavljevic
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroR E Byrns
Sep 1, 1993·The American Review of Respiratory Disease·J XieS S Greenberg
Oct 1, 1993·The Journal of Trauma·T D JacobA B Peitzman
Jan 1, 1995·Journal of Gastroenterology and Hepatology·K F Decker, M Y Obolenskaya
Jul 1, 1996·Critical Care Medicine·L A DoughtyJ A Carcillo
Dec 1, 1996·Archives of Surgery·B G HarbrechtT R Billiar

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Citations

Mar 12, 2004·The Journal of Surgical Research·Sirish MaddaliJohn M Daly
Sep 2, 1999·The Surgical Clinics of North America·J R IzbickiT Kuechler
Apr 1, 2000·Clinical and Experimental Pharmacology & Physiology·S SatoiH Takahashi
May 8, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Satoshi AikoTadaaki Maehara
Jul 18, 2000·The Journal of Surgical Research·R Anup, K A Balasubramanian
Jul 5, 2005·European Journal of Anaesthesiology·G DeloguF Ippoliti
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·F A RecchiaT H Hintze

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