PMID: 6967197Jul 1, 1980Paper

Prolonged effects of large-dose methylprednisolone infusion in multiple sclerosis

Neurology
J L Trotter, W F Garvey

Abstract

Three daily 1-gm doses of methylprednisolone were administered to 12 patients with multiple sclerosis. Granulocytes, lymphocytes, T and B lymphocytes, lymphocyte transformation in response to several mitogens and one antigen, plasma cortisol, and serum IgM and IgA all returned to baseline within a few days. However, total white blood count, unstimulated lymphocyte incorporation of 3H-thymidine, hematocrit, serum IgG, and cerebrospinal fluid IgG synthesis remained altered 1 week after the infusion. The relationship of these changes to any clinical effects is unknown.

Citations

Apr 1, 1986·Journal of Neurology·R A Hughes
Jun 1, 1983·Italian Journal of Neurological Sciences·G AbbruzzeseC Loeb
May 10, 2007·Current Neurology and Neuroscience Reports·Eric C Klawiter, Anne H Cross
Feb 1, 1989·Research in Immunology·A T Reder
Dec 1, 1990·Australian and New Zealand Journal of Medicine·T J AndersonP M George
Aug 1, 1982·Annals of the Rheumatic Diseases·D A IsenbergM L Snaith
Feb 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·M P BarnesP J Tilley
May 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·D A CompstonA K Campbell
Dec 1, 1988·Journal of Neuroimmunology·A HaassK Schimrigk
Mar 1, 1994·The International Journal of Neuroscience·A DufourC Milanese
Jun 9, 2005·Expert Review of Neurotherapeutics·Ee Tuan Lim, Gavin Giovannoni
Feb 19, 2010·Expert Opinion on Pharmacotherapy·Nancy L KuntzUNKNOWN Network of US Pediatric Multiple Sclerosis Centers
Jul 21, 2004·Journal of the Neurological Sciences·Carlo PozzilliFrancesca Bagnato
Jul 1, 1981·Survey of Ophthalmology·R M BurdeJ W Gittinger
Jan 15, 2014·Medical Hypotheses·Mickael Bonnan
Apr 24, 2001·Lupus·W W Chatham, R P Kimberly
Dec 16, 2017·Annals of Neurology·Ariele L Greenfield, Stephen L Hauser
Oct 18, 2000·The Cochrane Database of Systematic Reviews·G FilippiniL Candelise
Nov 1, 2002·Expert Review of Neurotherapeutics·Douglas R Jeffery
Aug 1, 1994·Acta Neurologica Scandinavica·S T FrequinO R Hommes
Jul 1, 1997·Acta Neurologica Scandinavica·T WeiS L Lightman

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.