Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves in trinitrobenzene sulphonic acid colitis

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
J SimpsonR Spiller

Abstract

Diverticulitis causes recurrent abdominal pain associated with increased mucosal expression of mucosal galanin and substance P (SP). We studied changes in mucosal and myenteric plexus neuropeptides in adult rats using a model of colonic inflammation, trinitrobenzenesulphonic acid colitis. We assessed the effects on the pan-neuronal markers protein gene product 9.5 (PGP9.5) and neurofilament protein, as well as specific neuropeptides at 1, 2, 3, 4, 6, 8, 10 and 14 weeks. Following the acute injury there was macroscopic resolution of inflammation but minor microscopic abnormalities persisted. Percent area stained of mucosal PGP9.5 fell initially but average levels on days 21 and 28 levels were significantly elevated (P < 0.001), returning to normal by day 42. Percent area staining of PGP9.5 in the muscle rose immediately and remained significantly elevated at 70 days (P < 0.001). SP, neuropeptide K and galanin followed a similar overall pattern. SP to PGP9.5 ratio was significantly increased in the muscle both acutely (days 1-28) and in the long term (days 70 and 98), whereas the galanin to PGP9.5 ratio was significantly increased in the mucosa throughout the study. Low-grade chronic inflammation after an acute initial insult cau...Continue Reading

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Citations

Aug 21, 2010·Current Gastroenterology Reports·Behtash Ghazi Nezami, Shanthi Srinivasan
Jul 2, 2009·Clinical and Experimental Pharmacology & Physiology·P A HughesL A Blackshaw
Jul 28, 2012·Journal of Neurogastroenterology and Motility·Robin Spiller, Ching Lam
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May 21, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J SimpsonR C Spiller
Jan 7, 2014·Alimentary Pharmacology & Therapeutics·D J Humes, R C Spiller
Feb 24, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R C Spiller
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May 11, 2012·Digestive Diseases·Robin Spiller
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