PMID: 2107895Feb 17, 1990Paper

Prolonged endometrial stimulation associated with oestradiol implants

BMJ : British Medical Journal
K GangarM Cust

Abstract

To provide information on endometrial stimulation after discontinuation of treatment with oestradiol implants. Long term follow up of withdrawal bleeding patterns in women taking progestogens cyclically every month after oestradiol implant treatment was ended. Specialist menopause clinic. 10 Postmenopausal patients (at least 12 months' amenorrhoea after the last spontaneous period) who were treated with oestradiol implants for typical symptoms of oestrogen deficiency. The oestradiol dose was 50 mg, reimplantation occurring roughly every six months. Patients subsequently either needed to discontinue the hormone treatment for medical reasons or expressed a desire to stop treatment. Duration of endometrial stimulation--defined as the presence of withdrawal bleeding in response to progestogen given cyclically--after insertion of the last oestradiol implant. Four patients eventually stopped bleeding, their mean duration of bleeding being 35 months (range 27-43 months). One patient required hysterectomy 26 months after the last implantation because of persistent irregular bleeding despite treatment with high doses of progestogen. Three patients bled for 22, 30, and 36 months and then restarted oestrogen treatment because symptoms ret...Continue Reading

References

Mar 1, 1989·British Journal of Cancer·A Paganini-HillB E Henderson
Aug 15, 1985·American Journal of Obstetrics and Gynecology·M L PadwickM I Whitehead
Aug 15, 1985·American Journal of Obstetrics and Gynecology·M I WhiteheadJ Pryse-Davies
Apr 1, 1981·British Journal of Obstetrics and Gynaecology·M H ThomJ W Studd
Mar 22, 1980·British Medical Journal·M E PatersonJ W Studd

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Citations

Feb 1, 1992·Lancet·S Bewley, T H Bewley
Jan 1, 1993·Baillière's Clinical Endocrinology and Metabolism·J W Studd, R N Smith
Mar 26, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Jo Marsden
Oct 23, 1997·British Journal of Obstetrics and Gynaecology·D W Sturdee
Sep 24, 1999·British Journal of Obstetrics and Gynaecology·A O'LearyU Rajesh
Jul 14, 2007·Journal of Women's Health·Michael Cirigliano
Mar 2, 2006·Expert Opinion on Drug Delivery·Ian S Fraser, Diana Mansour
May 3, 2003·Climacteric : the Journal of the International Menopause Society·C DomoneyA Mocroft
Apr 1, 1993·British Journal of Obstetrics and Gynaecology·K F GangarR W Beard
Jun 16, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A T LeatherE F Holland
Sep 9, 2010·The Cochrane Database of Systematic Reviews·Sharif I IsmailSuzanne Hagen

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