Prolonged eosinophil production after allergen exposure in IFN-gammaR KO mice is IL-5 dependent

Scandinavian Journal of Immunology
L-L ZhaoApostolos Bossios

Abstract

Asthma is a T helper 2 (Th2)-driven inflammatory process characterized by eosinophilia. Prolonged airway eosinophilia is commonly observed in asthma exacerbations. Our aim was to evaluate whether eosinophilia in prolonged allergic inflammation is associated with a continuous supply of new eosinophils to the airways, and how this is regulated. Ovalbumin (OVA)-sensitized interferon-gamma receptor knockout mice (IFN-gammaR KO), known to maintain a long-lasting eosinophilia after allergen exposure, were compared to wild type (wt) controls. Animals were exposed to OVA or phosphate-buffered saline on three consecutive days, and bone marrow (BM), blood and bronchoalveolar lavage (BAL) samples were collected 24 h, 7 and 21 days later. Newly produced cells were labelled using bromodeoxyuridine (BrdU). Serum IL-5 was measured and its role was investigated by administration of a neutralizing anti-IL-5 antibody. In-vitro eosinophilopoiesis was examined in both groups by a colony-forming assay. Allergen challenge increased eosinophils in BM, blood and BAL, in both IFN-gammaR KO and wt mice, both 24 h and 7 days after the last allergen exposure. At 21 days after the last exposure, only IFN-gammaR KO mice maintained significantly increased eo...Continue Reading

References

Nov 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G GibsonJ A Denburg
Oct 1, 1995·The Journal of Experimental Medicine·P D CollinsT J Williams
Jul 1, 1996·The Journal of Allergy and Clinical Immunology·A J FrewS T Holgate
Nov 1, 1996·American Journal of Respiratory Cell and Molecular Biology·R SehmiJ A Denburg
Nov 14, 1998·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·N G PapadopoulosP Saxoni-Papageorgiou
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·M D InmanP M O'Byrne
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M TomakiJ Lötvall
Mar 21, 2001·Apoptosis : an International Journal on Programmed Cell Death·A M VignolaG Bonsignore
Apr 26, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M RaisS Sur
Aug 7, 2002·Pharmacology & Therapeutics·Adrian J BaatjesJudah A Denburg
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·Makoto YoshidaMark D Inman
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Lin-Ying LiuWilliam W Busse
Aug 16, 2003·American Journal of Respiratory Cell and Molecular Biology·Brigita SitkauskieneJan Lötvall
Nov 25, 2003·American Journal of Respiratory and Critical Care Medicine·Sandra C DormanRoma Sehmi
Dec 6, 2003·American Journal of Respiratory and Critical Care Medicine·Sandra C DormanPaul M O'Byrne
Jun 23, 2004·The Journal of Allergy and Clinical Immunology·Madeleine RådingerJan Lötvall
Sep 24, 2004·European Journal of Immunology·Anna-Karin JohanssonJan Lötvall
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbara A StoutPaul J Bertics
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·David S SouthamRoma Sehmi
Jan 15, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S SergejevaT Pullerits
Feb 22, 2005·International Archives of Allergy and Immunology·Choon-Sik ParkIl Yup Chung
Aug 13, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Charlotte BarckGunnar Bylin
Aug 17, 2005·Scandinavian Journal of Immunology·V MuratovJ Lundahl
Mar 2, 2006·The European Respiratory Journal·J A Denburg, S F van Eeden
Mar 23, 2006·Annual Review of Immunology·Marc E Rothenberg, Simon P Hogan
Apr 4, 2006·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Dagmar SimonHans-Uwe Simon
Apr 14, 2006·Seminars in Respiratory and Critical Care Medicine·Harsha H Kariyawasam, Douglas S Robinson
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Marek LommatzschJ Christian Virchow
Nov 7, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S Romagnani
Nov 25, 2006·International Archives of Allergy and Immunology·Hiroshi Nakajima, Kiyoshi Takatsu

❮ Previous
Next ❯

Citations

Mar 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M BensonL O Cardell
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·Josephine de KluijverPeter J Sterk
Aug 16, 2003·American Journal of Respiratory Cell and Molecular Biology·Brigita SitkauskieneJan Lötvall
Dec 5, 2006·American Journal of Respiratory Cell and Molecular Biology·Stefan IvanovAnders Lindén
Aug 25, 2019·Allergy·Stefanie EyerichKilian Eyerich
Apr 8, 2010·The Journal of Allergy and Clinical Immunology·Anne M FitzpatrickUNKNOWN National Institutes of Health/National Heart, Lung, and Blood Institute's Severe Asthma Research Program

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.