Prolonged function of canine pancreatic fragments autotransplanted to the spleen by venous reflux

Transplantation
N M KnetemanR V Rajotte

Abstract

The long-term viability and function of pancreatic islets transplanted as nonvascularized dispersed grafts has not been well established. We report maintenance of nondiabetic carbohydrate metabolism for up to 36 months (17.8 +/- 1.4 months) in 77% of 40 consecutive canine recipients of nonpurified islet grafts transplanted to the spleen by venous reflux. Spontaneous loss of graft function occurred in 9 dogs during the follow-up period. Failure usually occurred within 1 year of implantation and was predicted by low K value and low insulin output on intravenous glucose tolerance tests 1 and 3 months postimplant. High K values and insulin output correlated strongly with maintenance of function beyond 24 months. A sufficient mass of implanted islets can provide satisfactory metabolic control for prolonged periods.

Citations

Apr 9, 1998·Transplantation Proceedings·S A WhiteA R Dennison
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Aug 17, 2002·Journal of Biomaterials Science. Polymer Edition·NatsukiIwanaga Asuka NagataYasuhiko Tabata
May 25, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Seok L OngAshley R Dennison
Oct 21, 2004·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·E AshtonS W McDonald
Jun 10, 2014·Veterinary Surgery : VS·Daniela VrabelovaAmer Rajab
Jun 27, 2006·Transplantation Proceedings·T XiaohuiF Xinshun
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Aug 24, 2017·BMC Veterinary Research·Stephen HarringtonLisa Stehno-Bittel
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