PMID: 9434706Jan 22, 1998Paper

Prolonged hemodynamic stability during arteriovenous carbon dioxide removal for severe respiratory failure

The Journal of Thoracic and Cardiovascular Surgery
R L BrunstonJ B Zwischenberger

Abstract

The effects of prolonged arteriovenous carbon dioxide removal on hemodynamics during severe respiratory failure were evaluated in adult sheep with severe smoke inhalation injury. Adult female sheep (n = 6,33.8 +/- 5.2 kg) were subjected to intratracheal cotton severe smoke insufflation to a mean carboxyhemoglobin level of 83% +/- 3%. Twenty-four hours after injury, a low-resistance 2.5 m2 membrane oxygenator was placed in a carotid-to-jugular pumpless arteriovenous shunt at unrestricted flow to allow complete carbon dioxide removal and reductions in ventilator support. Animals remained conscious, and heart rate, cardiac output, mean arterial pressure, and pulmonary arterial pressure were measured at baseline, after injury, and daily during support with the arteriovenous carbon dioxide removal circuit for 7 days. All animals survived the study period. Carbon dioxide removal ranged from 99.7 +/- 13.7 to 152.2 +/- 16.2 ml/min, and five (83%) of the six animals were successfully weaned from the ventilator before day 7. During full support with the arteriovenous carbon dioxide removal circuit, shunt flow ranged from 1.24 +/- 0.06 to 1.43 +/- 0.08 L/min and accounted for 20.1% +/- 1.4% to 25.9% +/- 2.4% of cardiac output. No statisti...Continue Reading

References

Mar 1, 1992·The Journal of Trauma·L M GentilelloG J Jurkovich
Apr 1, 1991·The Annals of Thoracic Surgery·J A AwadL Martin
May 1, 1991·The American Review of Respiratory Disease·K TsunoT Morioka
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Jan 22, 1998·The Annals of Thoracic Surgery·R L BrunstonA Bidani

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Citations

Oct 4, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Dongfang WangJoseph B Zwischenberger
Dec 6, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Dongfang WangJoseph B Zwischenberger
Sep 15, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Dongfang WangSean D Chambers
Nov 30, 2004·Critical Care : the Official Journal of the Critical Care Forum·Balagangadhar R TotapallyJack Wolfsdorf
Oct 16, 2012·Burns : Journal of the International Society for Burn Injuries·Sven AsmussenMarc O Maybauer
Jan 15, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Joerg BrederlauNorbert Roewer
Jul 19, 2002·Chest Surgery Clinics of North America·Scott K Alpard, Joseph B Zwischenberger
Mar 7, 2006·The Journal of Thoracic and Cardiovascular Surgery·Stefan FischerMartin Strueber
Jul 12, 2012·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Alexandre Peixoto CosciaAndre Miguel Japiassu
Jul 26, 2002·Perfusion·Joseph B Zwischenberger, Scott K Alpard

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