Prolonged improvement of Raynaud's phenomenon and scleroderma after recombinant tissue plasminogen activator therapy

Arthritis and Rheumatism
M J Fritzler, D A Hart

Abstract

We describe a patient with systemic sclerosis (SSc; scleroderma) characterized by severe Raynaud's phenomenon, cutaneous sclerosis, and digital ulceration and subsequent amputation who was treated with recombinant tissue plasminogen activator (rt-PA) after acute myocardial infarction. She showed prompt improvement of the Raynaud's phenomenon and healing of the digital ulceration. After 18 months of followup, the Raynaud's phenomenon has remained mild, and there has been improvement in the cutaneous sclerosis. Since the pathophysiology of SSc has been associated with disorders of fibrinolysis and coagulation, this patient represents an interesting index case that might prompt further evaluation of rt-PA therapy in carefully selected patients.

References

Jun 1, 1979·The Journal of Experimental Medicine·M B KahalehE C LeRoy
May 1, 1975·Seminars in Arthritis and Rheumatism·P M Campbell, E C LeRoy
Dec 1, 1975·The British Journal of Dermatology·N L FureyH H Friederici
Mar 30, 1989·The New England Journal of Medicine·E Rapaport
Jul 1, 1985·Arthritis and Rheumatism·V D SteenT A Medsger

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Citations

Jan 1, 1991·International Journal of Clinical & Laboratory Research·A AgostoniM Cugno
Sep 12, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·C Sunderkötter, G Riemekasten
Nov 28, 2008·Rheumatology International·Sevdalina Nikolova Lambova, Ulf Müller-Ladner
Mar 29, 2005·Zeitschrift für Rheumatologie·G Riemekasten, H Schulze-Koops
May 1, 1992·Clinical Immunology and Immunopathology·L R ZacharskiE M Nutt
Nov 1, 1992·The American Journal of the Medical Sciences·J D Smiley

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