Prolonged infusion of estradiol benzoate into the stalk median eminence stimulates release of GnRH and kisspeptin in ovariectomized female rhesus macaques

Endocrinology
Brian P KenealyE Terasawa

Abstract

Our recent study indicates that a brief infusion (20 min) of estradiol (E2) benzoate (EB) into the stalk-median eminence (S-ME) stimulates GnRH release with a latency of approximately 10 minutes. In contrast to the effect induced by a brief infusion of EB, it has previously been shown that systemic EB administration suppresses release of GnRH, kisspeptin, and LH with a latency of several hours, which is known as the negative feedback action of E2. We speculated that the differential results by these 2 modes of EB administration are due to the length of E2 exposure. Therefore, in the present study, the effects of EB infusion for periods of 20 minutes, 4 hours, or 7 hours into the S-ME of ovariectomized female monkeys on the release of GnRH and kisspeptin were examined using a microdialysis method. To assess the effects of the EB infusion on LH release, serum samples were also collected. The results show that similar to the results with 20-minute infusion, both 4- and 7-hour infusions of EB consistently stimulated release of GnRH and kisspeptin from the S-ME accompanied by LH release in the general circulation. In contrast, sc injection of EB suppressed all 3 hormones (GnRH, kisspeptin, and LH) measured. It is concluded that rega...Continue Reading

References

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Sep 4, 2012·Frontiers in Neuroendocrinology·Ei Terasawa, Brian P Kenealy
May 31, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie ConstantinAllan E Herbison
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Dec 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian P KenealyEi Terasawa
Feb 1, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mohammed A KhayumJanine Doorduin

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Citations

Oct 28, 2017·Nature Reviews. Endocrinology·Jerome Clasadonte, Vincent Prevot
Nov 1, 2017·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Charlotte A Cornil
Dec 13, 2017·Proceedings of the National Academy of Sciences of the United States of America·Brian P KenealyEi Terasawa

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