Prolonged inhaled NO attenuates hypoxic, but not monocrotaline-induced, pulmonary vascular remodeling in rats

Anesthesia and Analgesia
D J HorstmanG F Rich

Abstract

In concentrations of 10-20 ppm, inhaled nitric oxide (NO) decreases pulmonary artery pressure and attenuates vascular remodeling in pulmonary hypertensive rats. Because NO is potentially toxic, it is important to know whether lower concentrations attenuate vascular remodeling produced by different etiologies. Therefore, we determined the effects of prolonged, small-dose inhaled NO administration on hypoxic and monocrotaline (MCT)-induced pulmonary vascular remodeling. Rats were subjected to normoxia, hypoxia (normobaric 10% oxygen), or hypoxia plus NO in concentrations of 50 ppb, 200 ppb, 2 ppm, 20 ppm, and 100 ppm for 3 wk. A second group of normoxic rats was given MCT (60 mg/kg intraperitoneally) alone or in the presence of 2, 20, and 100 ppm of NO. Subsequently, pulmonary artery smooth muscle thickness and the number of muscular arteries (percentage of total arteries) were determined. Right ventricular hypertrophy was determined by right to left ventricle plus septum weight ratio (RV/LV + S). Pulmonary artery smooth muscle thickness and the percent muscular arteries were increased by hypoxia and MCT. The hypoxic increase in thickness was attenuated by all concentrations of NO, with 100 ppm being greatest, whereas NO had no e...Continue Reading

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Citations

Aug 26, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Maria E CampianHanno L Tan
Dec 26, 2001·Pharmacology & Therapeutics·T K Jeffery, J C Wanstall
Aug 4, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jason LeePravin B Sehgal
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Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward
Nov 26, 2003·Anesthesiology·Gilbert BlaiseBernard Hubert

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