Prolonged left ventricular contraction duration in apical segments as a marker of arrhythmic risk in patients with long QT syndrome.

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Karolina BorowiecElżbieta Katarzyna Biernacka

Abstract

Long QT syndrome (LQTS) is an inherited cardiac ion channelopathy predisposing to life-threatening ventricular arrhythmias and sudden cardiac death. The aim of this study was to investigate left ventricular mechanical abnormalities in LQTS patients and establish a potential role of strain as a marker of arrhythmic risk. We included 47 patients with genetically confirmed LQTS (22 LQT1, 20 LQT2, 3 LQT3, and 2 SCN3B) and 25 healthy controls. A history of cardiac events was present in 30 LQTS subjects. Tissue Doppler and speckle tracking echocardiography were performed and contraction duration was measured by radial and longitudinal strain. The radial strain characteristic was subdivided into two planes - the basal and the apical. Left ventricular ejection fraction and global longitudinal strain were normal in LQTS patients. Mean contraction duration was longer in LQTS patients compared with controls in regard to basal radial strain (491 ± 57 vs. 437 ± 55 ms, P < 0.001), apical radial strain (450 ± 53 vs. 407 ± 53 ms, P = 0.002), and longitudinal strain (445 ± 34 vs. 423 ± 43 ms, P = 0.02). Moreover, contraction duration obtained from apical radial strain analysis was longer in symptomatic compared with asymptomatic LQTS mutation c...Continue Reading

References

Jan 1, 1968·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·M Morad, W Trautwein
Aug 21, 2003·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·C SavoyeS Kacet
Sep 17, 2003·The Journal of Clinical Investigation·Robert S Kass, Arthur J Moss
Feb 20, 2007·Journal of the American College of Cardiology·Yasuhiko TakemotoJunichi Yoshikawa
Nov 26, 2008·Progress in Biophysics and Molecular Biology·Matthew J KilleenChristopher L-H Huang
Sep 6, 2011·Cardiac Electrophysiology Clinics·Charles Antzelevitch, Alexander Burashnikov
Oct 26, 2012·Congenital Heart Disease·Kristina H HaugaaMichael J Ackerman
Sep 3, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Silvia G PrioriUNKNOWN Asia Pacific Heart Rhythm Society
Apr 22, 2015·JACC. Cardiovascular Imaging·Ida S LerenKristina H Haugaa
May 6, 2015·JACC. Cardiovascular Imaging·Arshad Jahangir, Renuka Jain
May 10, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Johannes BradoKatja E Odening
Jun 21, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Elena Arbelo
Dec 14, 2017·Herzschrittmachertherapie & Elektrophysiologie·F F DresslerK E Odening

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Heart, Lung & Circulation
Jitu Vohra
Journal of Electrocardiology
Wojciech Zareba, A J Moss
Journal of Cardiovascular Electrophysiology
Gordon F Tomaselli, Takeshi Aiba
© 2022 Meta ULC. All rights reserved