Prolonged local anesthetic action through slow release from poly (lactic acid co castor oil).

Pharmaceutical Research
Marina Sokolsky-PapkovCarolyn F Weiniger

Abstract

To evaluate a new formulation of bupivacaine loaded in an injectable fatty acid based biodegradable polymer poly(lactic acid co castor oil) in prolonging motor and sensory block when injected locally. The polyesters were synthesized from DL: -lactic acid and castor oil with feed ratio of 4:6 and 3:7 w/w. Bupivacaine was dispersed in poly(fatty ester) liquid and tested for drug release in vitro. The polymer p(DLLA:CO) 3:7 loaded with 10% bupivacaine was injected through a 22G needle close to the sciatic nerve of ICR mice and the duration of sensory and motor nerve blockade was measured. The DL: -lactic acid co castor oil p(DLLA:CO) 3:7 released 65% of the incorporated bupivacaine during 1 week in vitro. Single injection of 10% bupivacaine loaded into this polymer caused motor block that lasted 24 h and sensory block that lasted 48 h. Previously we developed a ricinoleic acid based polymer with incorporated bupivacaine which prolonged anesthesia to 30 h. The new polymer poly(lactic acid co castor oil) 3:7 provides slow release of effective doses of the incorporated local anesthetic agent and prolongs anesthesia to 48 h.

References

Jul 10, 2001·Pharmaceutical Research·G J GrantE M Bolotin
Dec 18, 2003·Clinical and Experimental Pharmacology & Physiology·G J GrantM Bansinath
Jun 16, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Daniele R de AraujoEneida de Paula
Jul 12, 2005·Biomacromolecules·Michal Y Krasko, Abraham J Domb
Jan 10, 2006·Biomacromolecules·Ariella Shikanov, Abraham J Domb
Jun 3, 2006·Pharmaceutical Research·Raia SlivniakAbraham J Domb
Dec 2, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ariella ShikanovCarolyn F Weiniger

❮ Previous
Next ❯

Citations

May 15, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Iyabo Oladunni BabasolaBrian G Amsden
Dec 23, 2011·Anesthesiology Research and Practice·Edward A Shipton
Apr 23, 2010·Expert Opinion on Drug Delivery·Carolyn F WeinigerA J Domb
Nov 22, 2013·Journal of Pharmaceutical Sciences·Diana E IckowiczCarolyn F Weiniger
Dec 17, 2009·Journal of Pharmaceutical Sciences·Marina Sokolsky-PapkovCarolyn F Weiniger
May 23, 2012·Anaesthesia·C F WeinigerD Ickowicz
Apr 15, 2014·International Journal of Pharmaceutics·D E IckowiczC F Weiniger
Sep 4, 2015·Journal of Anaesthesiology, Clinical Pharmacology·Prasanna VadhananS Adinarayanan
Jul 3, 2015·Journal of Translational Medicine·Anne Gomez-BrouchetVincent Minville
May 19, 2010·Journal of Neurosurgical Anesthesiology·Irene Osborn, Joseph Sebeo
Jul 1, 2011·Pharmaceutical Research·Marina Sokolsky-PapkovCarolyn F Weiniger
Sep 1, 2010·Comprehensive Reviews in Food Science and Food Safety·Majid JamshidianStéphane Desobry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.