Prolonged low-dose cyclophosphamide treatment after pulse therapy attenuates lung injury in rats with paraquat intoxication

The Korean Journal of Internal Medicine
J GaoYong Li

Abstract

This study tested the hypothesis that prolonged low-dose cyclophosphamide (CTX) treatment after pulse therapy attenuate paraquat (PQ)-induced lung injury in rats. PQ (25 mg/kg) was administered intraperitoneally to induce PQ-intoxicated rat model. The rats were randomly divided into four groups: control group (1 mL/day saline solution for 14 days), PQ group (1 mL/day saline solution for 14 days after PQ exposure), pulse group (15 mg/kg/day CTX in 1 mL of saline solution for 2 days and subsequent 1 mL/day saline solution for 12 days), and prolonged low-dose group (15 mg/kg/day CTX in 1 mL of saline solution for 2 days and subsequent 1.5 mg/kg/day CTX in 1 mL of saline solution for 12 days). A 14-day follow-up was conducted to determine the survival rat, and lung hydroxyproline (HYP), wet-to-dry weight ratios (W/Dc) and histopathological changes were evaluated. Results showed similar survival rate (55% vs. 50%, p > 0.05) between prolonged low-dose and pulse groups. Lung W/Dc (4.94 ± 0.38 vs. 5.47 ± 0.28, p < 0.01), HYP (3.34 ± 0.29 µg/mg vs. 3.65 ± 0.19 µg/mg, p < 0.001), and fibrosis score (2.69 ± 0.84 vs. 3.13 ± 0.63, p < 0.05) were lower in prolonged low-dose group than those in the pulse group. These findings suggested prolon...Continue Reading

References

Mar 1, 1992·Human & Experimental Toxicology·J H PerriënsH Chee
Jul 1, 1990·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·C BismuthC Keyes
Apr 1, 1988·Journal of Clinical Pathology·T AshcroftV Timbrell
Sep 1, 1971·Clinical Toxicology·A R BeebeejaunW N Rogers
Apr 1, 1966·British Journal of Industrial Medicine·D G ClarkE W Hurst
Apr 25, 2000·Human & Experimental Toxicology·M YamashitaY Ando
Jan 6, 2001·Medicina clínica·J Botella de Maglia, J E Belenguer Tarín
Jun 15, 2007·Free Radical Biology & Medicine·R J Dinis-OliveiraF Carvalho
Dec 29, 2007·Critical Reviews in Toxicology·R J Dinis-OliveiraF Carvalho
Feb 26, 2008·Clinics·Itamar Souza Oliveira-JúniorRicardo Martins Oliveira-Filho
May 9, 2008·Clinical Orthopaedics and Related Research·George A C MurrellMin-Xia Wang
May 5, 2012·Journal of Zhejiang University. Science. B·Qin ZhangYan Chen
Jul 19, 2013·The Korean Journal of Internal Medicine·Jae-Sung ChoiSae-Yong Hong
May 8, 2015·Toxicology International·Mehalingam VadivelanB S Suryanarayana

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Citations

Feb 3, 2021·Critical Reviews in Toxicology·Rajasekaran Subbiah, Rajnarayan R Tiwari

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