PMID: 69780Jul 23, 1977Paper

Prolonged maintained remissions of adult acute non-lymphocytic leukaemia

Lancet
B A Peterson, C D Bloomfield

Abstract

Maintenance chemotherapy consisting of weekly oral 6-thioguanine and intramuscular cytosine arabinoside was administered to 24 adult patients with acute non-lymphocytic leukaemia in complete remission. The median duration of complete remission was 16-5 months, with 9 patients (38%) still in their first remission after 18--56 months. 33% of the patients have been in continuous remission for over 2 yr, 21% for over 3 yr, and 12-5% for over 4 yr. Median survival so far is 22-5 months. This maintenance regimen is well tolerated, is easily administered on an outpatient basis, and produces substantial numbers of long-term remissions.

Citations

Aug 1, 1982·Cancer Genetics and Cytogenetics·D D HurdC D Bloomfield
Nov 1, 1983·European Journal of Cancer & Clinical Oncology·T Raposa
May 24, 1979·The New England Journal of Medicine·R P Gale
Aug 28, 1980·The New England Journal of Medicine·H J WeinsteinE Frei
Jan 1, 1989·The American Journal of the Medical Sciences·R S Stein
Jan 1, 1981·Leukemia Research·B A Peterson, C D Bloomfield
Oct 1, 1986·Disease-a-month : DM·K D SabbathP Calabresi
Sep 3, 2013·Clinical Medicine Insights. Oncology·Fuad El Rassi, Martha Arellano
May 29, 2018·Cancer·Martha Arellano, Jennifer Wilkinson Carlisle
Feb 1, 1990·American Journal of Hematology·D L UhlmanB A Peterson

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