Prolonged Microcatheter-Based Local Thrombolytic Infusion as a Salvage Treatment After Failed Endovascular Treatment for Cerebral Venous Thrombosis: A Multicenter Experience

Neurocritical Care
Adnan I QureshiM Fareed K Suri

Abstract

To determine the effectiveness of prolonged microcatheter-based local thrombolytic infusion in treatment of patients with cerebral venous thrombosis who achieved no or suboptimal recanalization with transvenous endovascular treatment. Data collection: Prospectively registries supplemented by retrospective review. Three hospitals with tertiary referral base. Patients who underwent transvenous endovascular treatment for cerebral venous thrombosis. Prolonged microcatheter-based local thrombolytic infusion of alteplase at the rate of 0.5-1 mg/h in patients in whom initial angiographic outcome was deemed suboptimal, either due to incomplete or no recanalization. Serial angiograms were performed to assess treatment response as follows: grade I, partial recanalization of one or more occluded dural sinuses with improved flow or visualization of branches; grade II, complete recanalization of one sinus but persistent occlusion of the other sinuses (A-no residual flow, B-nonocclusive flow); grade III, complete recanalization. Clinical outcome was determined at 1-3 months using modified Rankin scale. A total of 14 patients underwent 15 transvenous endovascular treatments. Initial treatment was considered suboptimal in 12/15 procedures due ...Continue Reading

References

Sep 7, 1991·Lancet·K M EinhäuplP Schmiedek
Jan 10, 1998·Clinical Cardiology·R Becker
Jun 3, 2000·Stroke; a Journal of Cerebral Circulation·K ChowF Viñuela
Sep 6, 2001·Stroke; a Journal of Cerebral Circulation·C A MolinaJ Alvarez-Sabín
Oct 9, 2004·Stroke; a Journal of Cerebral Circulation·José Alvarez-SabínMarta Rubiera
Oct 18, 2007·Current Opinion in Pulmonary Medicine·Francesco Dentali, Walter Ageno
Mar 15, 2008·Stroke; a Journal of Cerebral Circulation·Jan StamJim A Reekers
Oct 31, 2009·Journal of Vascular and Interventional Radiology : JVIR·William T KuoLawrence V Hofmann
Nov 3, 2009·Neurosurgical Focus·Maryam RahmanJ Mocco
Feb 27, 2010·Stroke; a Journal of Cerebral Circulation·Marie ThéaudinMarie-Germaine Bousser
Apr 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K EinhäuplUNKNOWN European Federation of Neurological Societies
Feb 5, 2011·Stroke; a Journal of Cerebral Circulation·Gustavo SaposnikUNKNOWN American Heart Association Stroke Council and the Council on Epidemiology and Prevention
Jul 1, 2014·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Fazeel M SiddiquiJan Stam
Feb 11, 2015·Journal of Neurology·Susanna M ZuurbierJonathan M Coutinho
Apr 23, 2015·Stroke; a Journal of Cerebral Circulation·Fazeel M SiddiquiJonathan M Coutinho
Apr 14, 2016·Annals of Intensive Care·Benjamin SoyerDidier Payen
Jun 15, 2017·Journal of the American Heart Association·Kristin SalottoloDavid Bar-Or

❮ Previous
Next ❯

Citations

Sep 15, 2020·Journal of Pharmacy Practice·Danine P SullingerSalia Farrokh
Feb 4, 2021·Aging and Disease·Chaobo BaiRan Meng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences
Maxim MokinAdnan H Siddiqui
Arquivos brasileiros de cardiologia
L C AlbuquerqueJ B Petracco
© 2022 Meta ULC. All rights reserved