PMID: 15332447Aug 31, 2004Paper

Prolonged mild hypoxia modifies human circadian core body temperature and may be associated with sleep disturbances

Chronobiology International
Olivier CosteYvan Touitou

Abstract

Fatigue is often reported after long-haul airplane flights. Hypobaric hypoxia, observed in pressurized cabins, may play a role in this phenomenon by altering circadian rhythms. In a controlled cross-over study, we assessed the effects of two levels of hypoxia, corresponding to cabin altitudes of 8000 and 12,000 ft, on the rhythm of core body temperature (CBT), a marker of circadian rhythmicity, and on subjective sleep. Twenty healthy young male volunteers were exposed for 8 h (08:00-16:00 h) in a hypobaric chamber to a cabin altitude of 8000 ft and, 4 weeks later, 12,000 ft. Each subject served as his own control. For each exposure, CBT was recorded by telemetry for two 24h cycles (control and hypoxic exposure). After filtering out nonphysiological values, the individual CBT data were fitted with a five-order moving average before statistical group analysis. Sleep latency, sleep time, and sleep efficiency were studied by sleep logs completed every day in the morning. Our results show that the CBT rhythm expression was altered, mainly at 12,000 ft, with a significant increase of amplitude and a delay in the evening decline in CBT, associated with alterations of sleep latency. Mild hypoxia may therefore alter circadian structure ...Continue Reading

References

Jan 1, 1992·Journal of Biological Rhythms·E N Brown, C A Czeisler
Feb 1, 1991·Ergonomics·H C Beh, P J McLaughlin
Feb 1, 1997·Perceptual and Motor Skills·H C Beh, P McLaughlin
Apr 1, 1997·The American Journal of Physiology·L GarciaP Sartor
Nov 14, 1997·Journal of Sleep Research·A E HiddingaR H Van den Hoofdakker
Mar 26, 1998·Biological Psychiatry·D L HamilosJ F Jones
Jul 17, 1999·The American Journal of Physiology·L PoncetL Denoroy
Feb 5, 2000·Journal of Applied Physiology·J P Mortola, E L Seifert
Jun 7, 2000·Chronobiology International·D Weinert
Jun 7, 2000·Chronobiology International·T H Monk, D J Kupfer
Jun 7, 2000·Chronobiology International·Y Touitou, E Haus
Aug 11, 2000·Respiration Physiology·K FenelonJ P Mortola
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B BishopG Farkas
Nov 25, 2000·Journal of Applied Physiology·T M Jarsky, R Stephenson
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T DanelY Touitou
Aug 17, 2002·Chronobiology International·Björn LemmerHeinz Lohrer
May 8, 2004·Chronobiology International·Yvan TouitouLudger Rensing

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Citations

Jan 31, 2006·Journal of Pineal Research·Yung-Wui TjongMan-Lung Fung
Mar 25, 2015·High Altitude Medicine & Biology·Dana M DiPasqualeMichael J Buono
Mar 13, 2014·Environmental Health : a Global Access Science Source·Eileen McNeelySteve Hecker
Mar 17, 2007·Chronobiology International·Olivier CosteYvan Touitou
Aug 4, 2016·Chronobiology International·Yvan TouitouAlain Reinberg
Mar 28, 2017·High Altitude Medicine & Biology·Yongsuk SeoEllen L Glickman
Jul 30, 2020·American Journal of Physiology. Cell Physiology·Emma J O'ConnellKristina M Cook
Dec 28, 2006·Chronobiology International·Gerard A KerkhofLudovic G P M van Amelsvoort
Jan 23, 2021·Journal of Biological Rhythms·Shaon SenguptaJane A McKeating
May 13, 2020·Trends in Endocrinology and Metabolism : TEM·Clara B Peek

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