Prolonged moderate elevation of corticosterone does not affect hippocampal anatomy or cell proliferation rates in mountain chickadees (Poecile gambeli)

Journal of Neurobiology
Vladimir V Pravosudov, Alicja Omanska

Abstract

Chronic stress and corresponding chronic elevations of glucocorticoid hormones have been widely assumed to have deleterious effects on brain anatomy and functions such as learning and memory. In particular, it has been suggested that chronic elevations of glucocorticoid hormones result in death of hippocampal neurons and in reduced rates of hippocampal neurogenesis. It is not clear, however, if any increase in glucocorticoid levels has negative effects on hippocampal anatomy as many animals regularly maintain moderately elevated levels of glucocrticoids over long periods of time under natural energetically demanding conditions. We used unbiased stereological methods to investigate whether mountain chickadees (Poecile gambeli) implanted for 49 days with continuous time-release corticosterone pellets, designed to approximately double the baseline corticosterone levels, differed from placebo-implanted chickadees in their hippocampal anatomy and cell proliferation rates. We found no significant differences between corticosterone and placebo-implanted birds in either telencephalon volume, volume of the hippocampal formation, or the total number of hippocampal neurons. Cell proliferation rates, measured as the total number of BrdU-la...Continue Reading

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Citations

Nov 23, 2005·Behavioral Neuroscience·Vladimir V PravosudovAlicja Omanska
Sep 28, 2006·Proceedings. Biological Sciences·Vladimir V PravosudovAlicja Omanska
Nov 27, 2009·Proceedings. Biological Sciences·Lara D LaDageVladimir V Pravosudov
Jun 24, 2009·Brain, Behavior and Evolution·Lara D LaDageVladimir V Pravosudov
Dec 10, 2013·Acta Neuropathologica·Paul J LucassenBoldizsár Czéh
Mar 4, 2008·Animal Behaviour·Vladimir V PravosudovThomas P Hahn
Jul 20, 2005·The European Journal of Neuroscience·Konrad LehmannGertraud Teuchert-Noodt
Jul 30, 2008·The European Journal of Neuroscience·Amnon KatzBarney A Schlinger
Oct 9, 2009·Developmental Neurobiology·Bernard A TarrTimothy J DeVoogd
May 6, 2006·Hormones and Behavior·Harold H Zakon
Dec 17, 2014·Frontiers in Neuroendocrinology·David F Sherry, Scott A MacDougall-Shackleton
Dec 7, 2017·PloS One·Barbara-Anne RobertsonTom V Smulders
May 18, 2006·Reviews in the Neurosciences·Tom Victor Smulders
Sep 22, 2019·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Laura W GlassmanL Michael Romero

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