Prolonged multifocal electroretinographic implicit times in the ocular ischemic syndrome

Investigative Ophthalmology & Visual Science
Peter Kristian KofoedMichael Larsen

Abstract

Purpose. To examine retinal function in chronic ocular ischemia using multifocal electroretinography (mfERG). Methods. Thirteen patients with unilateral ocular ischemic syndrome (OIS) underwent assessment of ophthalmic systolic blood pressure by ocular pneumoplethysmography, carotid artery patency by ultrasonography, intraocular pressure (IOP) by applanation tonometry, retinal perfusion by fluorescein angiography, and retinal function by mfERG. Results. Ophthalmic systolic blood pressure was 67.0 +/- 11.6 mm Hg in eyes with OIS and 106.1 +/- 18.0 mm Hg in fellow eyes, whereas IOP was 13.8 +/- 3.2 and 14.4 +/- 1.7 mm Hg, respectively. Summed mfERG implicit times (N1, P1, N2) were prolonged in eyes with OIS, by 7.6%, 6.2%, and 7.5%, respectively, compared with fellow eyes (P < or = 0.0048). The retardation of retinal function was significant outside the macula, whereas the assessment of responses from the central retina was limited by high variance. Second-order kernel (first slice) summed implicit times (N1, P1, N2) were also prolonged in OIS, by 6.6%, 7.3%, and 6.8%, respectively (P < or = 0.0058). Of the amplitudes, only the second-order N2 amplitude was significantly abnormal, being reduced by 23.2% in OIS (P = 0.011). Conclu...Continue Reading

Associated Clinical Trials

Citations

Aug 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Barbara Terelak-BorysIwona Grabska-Liberek
Oct 28, 2015·Journal of Ophthalmology·Dong Yoon KimSung Jae Yang
Oct 29, 2018·Acta Ophthalmologica·Oliver Niels KlefterMichael Larsen
Jun 12, 2012·Acta Ophthalmologica·Peter Kristian KofoedMichael Larsen
Jan 12, 2021·Journal of Pineal Research·Rong HuangXiaoling Liang

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