Prolonged oral treatment with an essential amino acid L-leucine does not affect female reproductive function and embryo-fetal development in rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Kazunori MawatariTakeshi Kimura

Abstract

L-leucine, an essential amino acid, is one of the most popular ingredients in dietary supplements. To investigate a possibility of its embryo-fetal toxicity in rats, 11- to 12-week old dams were orally administered an aqueous solution of L-leucine at doses of 300 or 1000 mg/kg body weight on gestational days 7-17. Body weight and feed intake was evaluated throughout the whole course of pregnancy (days 0-20). L-Leucine did not influence body weight, but at a dose of 1000 mg/kg, slightly enhanced feed intake on days 14 and 18 of pregnancy. Caesarean section (day 20) revealed no influences on the litter size and weight of live-born fetuses, the number of corpora lutea, implantation index or the quality of placenta, and the minor increase in feed intake was considered irrelevant to the pregnancy outcomes. Fetuses were evaluated in a battery of external, visceral and skeletal examinations. No effects of L-leucine on gender ratio and external abnormalities, and no significant treatment-related variations in visceral and skeletal pathologies were observed. These results suggested that L-leucine, administered orally during organogenesis at doses up to 1000 mg/kg body weight, did not affect the outcome of pregnancy and did not cause fet...Continue Reading

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Citations

Jan 28, 2017·Journal of Animal Science and Biotechnology·Shihai ZhangShiyan Qiao
Jan 24, 2018·International Journal of Toxicology·Robin A ReddemanIlona Pasics Szakonyiné
Sep 7, 2012·The American Journal of Clinical Nutrition·Rajavel ElangoPaul B Pencharz
Oct 19, 2012·The Journal of Nutrition·Paul B PencharzRonald O Ball
Jun 3, 2005·The Journal of Nutrition·David H Baker
Jun 3, 2005·The Journal of Nutrition·Kaori MatsuzakiTakeshi Kimura
Jun 3, 2005·The Journal of Nutrition·Marc YudkoffItzhak Nissim

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