Prolonged Outbreak of Mycobacterium chimaera Infection After Open-Chest Heart Surgery

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Hugo SaxRainer Weber

Abstract

Invasive Mycobacterium chimaera infections were diagnosed in 2012 in 2 heart surgery patients on extracorporeal circulation. We launched an outbreak investigation to identify the source and extent of the potential outbreak and to implement preventive measures. We collected water samples from operating theaters, intensive care units, and wards, including air samples from operating theaters. Mycobacterium chimaera strains were characterized by randomly amplified polymorphic DNA polymerase chain reaction (RAPD-PCR). Case detection was performed based on archived histopathology samples and M. chimaera isolates since 2006, and the patient population at risk was prospectively surveyed. We identified 6 male patients aged between 49 and 64 years with prosthetic valve endocarditis or vascular graft infection due to M. chimaera, which became clinically manifest with a latency of between 1.5 and 3.6 years after surgery. Mycobacterium chimaera was isolated from cardiac tissue specimens, blood cultures, or other biopsy specimens. We were able also to culture M. chimaera from water circuits of heater-cooler units connected to the cardiopulmonary bypass, and air samples collected when the units were in use. RAPD-PCR demonstrated identical pat...Continue Reading

References

Sep 16, 1988·JAMA : the Journal of the American Medical Association·G C du MoulinJ Hedley-Whyte
Jul 1, 1972·Thorax·W C Geldof, A G Brom
Jun 1, 1983·Annals of Internal Medicine·J N KuritskyR J Wallace
Apr 1, 1981·The Journal of Infectious Diseases·P C HoffmanC U Mauney
Apr 1, 2000·Applied and Environmental Microbiology·R H TaylorM W LeChevallier
Jun 1, 2002·Applied and Environmental Microbiology·Chiao-Tang ChangShiao-Ping Huang
Sep 14, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hana M El SahlyEdward A Graviss
Aug 2, 2003·Emerging Infectious Diseases·Joseph O Falkinham
Jul 29, 2004·International Journal of Systematic and Evolutionary Microbiology·Enrico TortoliClaudio Scarparo
Dec 19, 2006·The Journal of Hospital Infection·J H ShinJ N Lee
Feb 6, 2007·American Journal of Respiratory and Critical Care Medicine·David E GriffithUNKNOWN Infectious Disease Society of America
Sep 12, 2007·Journal of Occupational and Environmental Hygiene·Craig S GlazerCecile S Rose
Jan 23, 2008·Journal of Water and Health·Joseph O FalkinhamDick van Soolingen
Mar 24, 2010·The Journal of Infection·T M V StrabelliDavid Everson Uip
Sep 24, 2011·Journal of Medical Case Reports·Stéphan Cohen-BacrieMichel Drancourt
Mar 29, 2013·Journal of Clinical Microbiology·Yvonne AchermannBarbara Hasse
May 22, 2013·International Journal of Medical Microbiology : IJMM·Michael HombachErik C Böttger
Jun 12, 2013·Emerging Infectious Diseases·Dragana VukovićSrdjan Stepanović
Aug 12, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Avish NagpalPritish K Tosh

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Citations

Jan 27, 2016·Der Internist·F C Ringshausen, J Rademacher
Dec 5, 2015·Genome Announcements·Micheál Mac AogáinThomas R Rogers
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hajime KanamoriWilliam A Rutala
Mar 30, 2016·Current Environmental Health Reports·Joseph O Falkinham
Apr 27, 2016·The Journal of Hospital Infection·M I GarveyP Jumaa
May 24, 2016·The Journal of Hospital Infection·C DupontS Romano-Bertrand
Apr 23, 2016·The Journal of Hospital Infection·T GöttingW Ebner
May 25, 2016·The Journal of Hospital Infection·R SommersteinJ Marschall
May 31, 2016·The Journal of Hospital Infection·P N HoffmanA Heggie
May 12, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Sebastian HallerTim Eckmanns
Oct 6, 2016·Open Forum Infectious Diseases·Nicholas TanAndrew D Badley
Aug 16, 2016·Infectious Disease Clinics of North America·Geeta Sood, Trish M Perl
Aug 16, 2016·Infectious Disease Clinics of North America·Shantini D GamageGary A Roselle
Oct 16, 2016·MMWR. Morbidity and Mortality Weekly Report·Kiran M PerkinsJoseph F Perz
Oct 26, 2016·PLoS Neglected Tropical Diseases·Jennifer R HondaMichael Strong
Dec 6, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·James Owen RobinsonStanley Pang
Dec 6, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Franziska C TrudzinskiSören L Becker
Dec 6, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Marc J Struelens, Diamantis Plachouras
Dec 9, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hajime KanamoriWilliam A Rutala
Dec 9, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Meera ChandNick Phin
Jan 25, 2017·Annals of the American Thoracic Society·Rachel ThomsonAnastasios Konstantinos
Mar 21, 2017·Current Opinion in Infectious Diseases·Garth Dixon, Georgi Christov
Apr 22, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alexandre R MarraMichael B Edmond
Dec 31, 2016·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Yi CaiJohnathan R Renew
May 26, 2017·Current Opinion in Infectious Diseases·Peter W Schreiber, Hugo Sax
Jul 12, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Gina OdaMark Holodniy
Mar 29, 2018·QJM : Monthly Journal of the Association of Physicians·H HallR Aul
Aug 5, 2017·Genome Announcements·Nabeeh A HasanAlison Laufer Halpin
Sep 26, 2017·Internal Medicine·Hiroyuki FujikuraKeiichi Mikasa
Apr 29, 2018·Current Infectious Disease Reports·Geehan SuleymanAna Cecilia Bardossy
Feb 2, 2018·Clinical Microbiology Reviews·Betty A ForbesMichael L Wilson
Aug 3, 2018·British Journal of Hospital Medicine·S RokadiyaS Tiberi
Aug 4, 2018·Clinical Medicine : Journal of the Royal College of Physicians of London·Shailesh Dalvi, Paul Das
Aug 30, 2018·Perspectives in Public Health
Mar 31, 2017·Journal of Clinical Microbiology·Simone MokMargaret Fitzgibbon
Apr 7, 2017·Journal of Clinical Microbiology·Enrique Zozaya-ValdésTimothy P Stinear
Aug 11, 2018·Plastic and Reconstructive Surgery·Becher Al-HalabiOmar Fouda Neel
Nov 16, 2018·Clinical Microbiology Reviews·Carlos Franco-ParedesAlexandro Bonifaz
Oct 30, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shannon H Kasperbauer, Charles L Daley
Oct 23, 2018·The American Journal of Surgical Pathology·Nafis ShafizadehJim Nomura

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