Prolonged overall survival in gastric cancer patients after adoptive immunotherapy

World Journal of Gastroenterology : WJG
Guo-Qing ZhangShunchang Jiao

Abstract

To assess the efficacy of immunotherapy with expanded activated autologous lymphocytes (EAALs) in gastric cancer. An observational study was designed to retrospectively analyze the clinical data of 84 gastric cancer patients, of whom 42 were treated by EAAL immunotherapy plus conventional treatment and another 42 only received conventional treatment (control group). EAALs were obtained by proliferation of peripheral blood mononuclear cells from patients followed by phenotype determination. Clinical data including age, gender, clinical stage, chemotherapeutic regimens, hospitalization, surgical, radiotherapy, and survival data were collected along with EAAL therapy details and side effects. Patients were followed and the relationship between treatment and overall survival (OS) data obtained for the immunotherapy and control groups were compared retrospectively. The safety of EAAL immunotherapy was also evaluated. After in vitro culture and proliferation, the percentages of CD3+, CD3+CD8+, CD8+CD27+, CD8+CD28+, and CD3+CD16+/CD56+ cells increased remarkably (P < 0.05), while the percentages of CD3+CD4+, CD4+CD25+, and CD3-CD16+/CD56+ (natural killer cells) were overtly decreased (P < 0.05); no significant change was observed in C...Continue Reading

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Citations

May 31, 2018·International Journal of Molecular Sciences·Riccardo DolcettiVincenzo Canzonieri
Nov 6, 2018·Briefings in Functional Genomics·Qingfang ZhaoFeiling Cao
Sep 1, 2018·World Journal of Gastroenterology : WJG·Daniela Cornelia LazărAdrian Goldiș
Aug 7, 2017·BioMed Research International·Mohamed AbozeidRoberta Sommaggio
Nov 18, 2021·Immunotherapy·Christo KoleDimitrios Schizas

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