Prolonged sedation with propofol in the rat does not result in sleep deprivation

Anesthesia and Analgesia
A TungW B Mendelson

Abstract

The use of propofol provides sedation without prolonging emergence in patients in the Intensive Care Unit. When prolonged, however, continuous sedation may overlap with naturally occurring sleep periods and potentially increase the risk of sleep deprivation. We modified an established rat model of sleep to determine whether prolonged, continuous sedation results in sleep deprivation. Rats were continuously sedated for a 12-h period overlapping completely with their normal sleep phase. Electroencephalogram (EEG) and movement data were collected before and after the sedation period. Rats were evaluated for EEG and movement evidence of sleep deprivation after sedation. When compared with baseline, the time spent in rapid eye movement (REM) and non-REM sleep was decreased during the first 4 h after sedation. The duration of non-REM sleep bouts was not altered. Power in the delta band (0.5-4 Hz) during non-REM sleep was diminished during the first 2 h only. Movements were reduced during the first hour after emergence from sedation only. In summary, no EEG or behavioral evidence of sleep deprivation was observed on emergence from sedation. These results imply that sedation is associated with a restorative process reversing the natura...Continue Reading

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Citations

Apr 17, 2008·PloS One·Elizabeth A ClementClayton T Dickson
Apr 27, 2010·Anesthesia and Analgesia·George A MashourGina R Poe
Feb 23, 2013·Anesthesiology·Nobuo SasakiMatthias Eikermann
Mar 19, 2019·Anesthesia and Analgesia·Helene BenvenisteNora D Volkow
Nov 14, 2008·Chronobiology International·Garance DispersynYvan Touitou
Jul 4, 2012·Intensive Care Medicine·Eumorfia KondiliDimitris Georgopoulos
Feb 27, 2013·Current Anesthesiology Reports·Matthew T Scharf, Max B Kelz
Jan 12, 2011·Journal of Intensive Care Medicine·Biren B KamdarNancy A Collop
Jan 23, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Bruno van Swinderen, Benjamin Kottler
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Nov 25, 2005·Anesthesiology·Ralph Lydic, Helen A Baghdoyan
Dec 18, 2010·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hwan-Soo JangMaan-Gee Lee
Apr 22, 2008·Nature Reviews. Neuroscience·Nicholas P Franks
May 31, 2020·The Journal of Comparative Neurology·Robert P Vertes, Stephanie B Linley
Apr 16, 2021·Anesthesia and Analgesia·Olivia A MoodyKen Solt
May 27, 2008·Sleep Medicine Reviews·Xavier DrouotLaurent Brochard
Jun 10, 2008·Critical Care Clinics·Gerald L Weinhouse

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