Prolonged sensory-selective nerve blockade.

Proceedings of the National Academy of Sciences of the United States of America
Itay Sagie, Daniel S Kohane

Abstract

Sensory-selective local anesthesia has long been a key goal in local anesthetic development. For example, it allows women to be pain-free during labor without compromising their ability to push. Here we show that prolonged sensory-selective nerve block can be produced by specific concentrations of surfactants-such as are used to enhance drug flux across skin-in combination with QX-314, a lidocaine derivative that has relative difficulty penetrating nerves. For example, injection of 25 mM QX-314 in 30 mM octyltrimethylammonium bromide (OTAB) lasted up to 7 h. Sensory selectivity was imparted to varying degrees by cationic, neutral, and anionic surfactants, and also was achieved with another lidocaine derivative, QX-222. Simultaneous injection of OTAB at a s.c. injection site remote from the sciatic nerve did not result in prolonged sensory-specific nerve blockade from QX-314, suggesting that the observed effect is due to a local interaction between the surfactant and the lidocaine derivative, not a systemic effect.

References

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Dec 25, 2008·Molecular Pharmaceutics·Emmanuel J SimonsDaniel S Kohane

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Citations

Apr 25, 2012·Molecular Pharmaceutics·Denise ZwanzigerIngolf E Blasig
Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Dagmar HackelHeike L Rittner
Apr 26, 2013·Cornea·Liqiang WangDaniel S Kohane
Mar 20, 2013·Basic & Clinical Pharmacology & Toxicology·Zhuo LiJing Yang
Jul 29, 2017·Advanced Materials·Rong YangDaniel S Kohane
Sep 9, 2017·Canadian Journal of Physiology and Pharmacology·Wenling ZhaoLinghui Yang
Oct 23, 2019·Translational Vision Science & Technology·Alan G WoodruffDaniel S Kohane
May 3, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jeong-Ho YoonDong-Kuk Ahn
Jan 21, 2021·Drug Design, Development and Therapy·Qi WangWensheng Zhang
Mar 7, 2019·Molecular Pharmaceutics·Rong YangDaniel S Kohane

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