Prolonged shedding of severe acute respiratory syndrome coronavirus 2 in patients with COVID-19.

Emerging Microbes & Infections
Qian LiPeng Zhou

Abstract

Following acute infection, individuals COVID-19 may still shed SARS-CoV-2 RNA. However, limited information is available regarding the active shedding period or whether infectious virus is also shed. Here, we monitored the clinical characteristics and virological features of 38 patients with COVID-19 (long-term carriers) who recovered from the acute disease, but still shed viral RNA for over 3 months. The median carrying history of the long-term carriers was 92 days after the first admission, and the longest carrying history was 118 days. Negative-positive viral RNA-shedding fluctuations were observed. Long-term carriers were mostly elderly people with a history of mild infection. Infectious SARS-CoV-2 was isolated from the sputum, where high level viral RNA was found. All nine full-length genomes of samples obtained in March-April 2020 matched early viral clades circulating in January-February 2020, suggesting that these patients persistently carried SARS-CoV-2 and were not re-infected. IgM and IgG antibodies and neutralizing-antibody profiles were similar between long-term carriers and recovered patients with similar disease courses. In summary, although patients with COVID-19 generated neutralizing antibodies, they may still ...Continue Reading

References

Jun 28, 2016·Nature Reviews. Microbiology·Emmie de WitVincent J Munster
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Apr 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jing YuanLei Liu
May 25, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Y ZhaoJ He
Jun 24, 2020·The Journal of Infection·Valeria CentoCarlo Federico Perno

❮ Previous
Next ❯

Citations

Feb 15, 2021·European Journal of Clinical Investigation·Stefan PilzFranz Allerberger
Mar 15, 2021·Echocardiography·Dena E HayesMuhamed Saric
Jul 18, 2020·Clinical Chemistry·Stanley J Naides
Apr 4, 2021·Viruses·Szilárd VáncsaPéter Hegyi
Mar 27, 2021·Epidemiology and Infection·Aparna MukherjeeSamiran Panda
Apr 30, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Fernando González-CandelasManuela Sironi
May 4, 2021·SN Comprehensive Clinical Medicine·Nevio Cimolai
Jul 20, 2021·Frontiers in Immunology·Rakhee K RamakrishnanImad M Tleyjeh
Nov 18, 2021·Microbiology Spectrum·Isabela de Carvalho LeitãoUNKNOWN on the behalf of the UFRJ-Covid19 Workgroup

❮ Previous
Next ❯

Datasets Mentioned

BETA
MN996528.1

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
PCR
ELISA

Software Mentioned

Geneious
XSEDE
MEGAHIT
GraphPad Prism
Clone Manager Suite
Adobe Illustrator CC
MAFFT
FigTree
ClustalW
BioEdit

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annali di igiene : medicina preventiva e di comunità
L B AlhusseiniM F Al Marjani
Human Vaccines & Immunotherapeutics
Firzan NainuHarapan Harapan
MedRxiv : the Preprint Server for Health Sciences
A. M. AliHassan Muhammad Rostam
Emerging Infectious Diseases
Natalia Fintelman-RodriguesThiago Moreno L Souza
© 2021 Meta ULC. All rights reserved