PMID: 8594025Nov 1, 1995Paper

Prolonged stimulation of respiration by brain stem metabotropic glutamate receptors

Journal of Applied Physiology
A Li, E E Nattie

Abstract

Stimulation of metabotropic glutamate receptors (mGluRs) in the retrotrapezoid nucleus (RTN) of chloralose-urethan-anesthetized rats by the mGluR agonist (1S,3R)-aminocyclopentanedicarboxylic acid [(1S,3R)-ACPD; 10 nl, 1 mM] increases integrated phrenic nerve amplitude (PNA) for > 60 min. Here we ask if the mGluR antagonist (+-)-alpha-methyl-4-carboxyphenylglycine [(+-)-MCPG] can block this effect. Using multibarreled micropipettes, we first identified RTN sites that affect respiration by noting short-lived stimulation of PNA produced by brief-duration injection of glutamate (10 nl, 100 mM), a presumed ionotropic receptor response. We then injected the active or inactive isomer of (+-)-MCPG (10 nl, 10 mM) followed by (1S,3R)-ACPD or by a long-duration (60-s) injection of glutamate (10 nl, 100 mM) at the same site. Each injection location was verified anatomically. The active antagonist (+-)-MCPG itself had no significant effect on PNA, but it blocked 1) subsequent (1S,3R)-ACPD-induced PNA stimulation for 99 +/- 11 (SE) min and 2) the PNA response to 60-s glutamate injection for 66 +/- 6 min. The inactive form (-)-MCPG had no effect on (1S,3R)-ACPD-induced PNA stimulation. We conclude that 1) RTN mGluRs may be involved in respir...Continue Reading

Citations

Sep 18, 1997·Journal of Applied Physiology·C L CreamE E Nattie
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alessandra CifraAndrea Nistri
Nov 5, 2004·American Journal of Physiology. Cell Physiology·Robert W PutnamNicola A Ritucci
May 23, 2012·Experimental Physiology·Ana C TakakuraEduardo Colombari
Nov 1, 1996·Journal of Applied Physiology·E E Nattie, A Li
Aug 24, 2002·The European Journal of Neuroscience·Fulvia BongianniTito Pantaleo
Jul 7, 2000·Pharmacology & Therapeutics·A HajiM Okazaki
Jul 25, 2021·Respiratory Physiology & Neurobiology·M J OlivaresJ Eugenín

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