PMID: 9191522Jun 15, 1997Paper

Prolonged survival of 2 years or longer for patients with disseminated melanoma. An analysis of related prognostic factors

Cancer
C U BrandC Garbe

Abstract

Once melanoma has metastasized to distant sites, the prognosis is usually poor, showing an overall median survival of 6-8 months. Long term survival is extremely rare, and there is still controversy concerning the prognostic significance of therapeutic modalities. The aim of the current study was to identify important prognostic factors associated with Stage IV melanoma. The current study was based on data for 3258 melanoma patients, for whom clinical, pathologic, and long term follow-up information was recorded during the period 1976-1996 at the Eberhard-Karls-University in Tuebingen. Germany. The attainment of 2 years' or longer survival time by patients with disseminated melanoma was addressed, and a multivariate analysis of related prognostic factors was performed by logistic regression. Four hundred forty-two patients (13.6%) developed distant metastasis. The median survival time was 7 months, and the 2-year, 5-year, and 10-year survival rates were 11.9%, 6.7%, and 4.7%, respectively. Forty-five patients had prolonged survival of 2 years or longer. Significantly more females belonged to the group of long term survivors (P = 0.0186). Of the modalities of therapy given, only surgery was associated with prolonged survival (P ...Continue Reading

Citations

Mar 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S MerkelP Hermanek
May 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chris C LeeDonald L Morton
Apr 12, 2011·Expert Review of Pharmacoeconomics & Outcomes Research·Upendra P HegdeJane M Grant Kels
Feb 6, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mengze HaoJilong Yang
Jun 15, 2010·Clinics in Dermatology·Andrea ForschnerClaus Garbe
Oct 22, 2008·Annales de dermatologie et de vénéréologie·F SarandiJ-L Moretti
Nov 23, 2006·Current Problems in Surgery·Cecelia E SchmalbachCarol R Bradford
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Apr 8, 2011·Cancer·Thomas K EigentlerUNKNOWN Dermatologic Cooperative Oncology Group and the National Interdisciplinary Working Group on Melanoma
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Apr 6, 2004·Facial Plastic Surgery Clinics of North America·Thong T Le, Karen T Pitman
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Aug 19, 2003·Seminars in Surgical Oncology·Charles M BalchJohn F Thompson

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