PMID: 11316327Apr 24, 2001Paper

Prolonged swim-test immobility of serotonin N-acetyltransferase (AANAT)-mutant mice

Journal of Pineal Research
Tolga Uz, Hari Manev

Abstract

Serotonin N-acetyltransferase (AANAT; EC 2.3.1.87) metabolizes serotonin into N-acetylserotonin (NAS). AANAT mRNA is expressed in the pineal gland and retina, and also in the rat brain. It was proposed that NAS could be a mediator of the antidepressant action of drugs, and it was shown that chronic but not acute treatment of rats with the antidepressant fluoxetine increases the content of AANAT mRNA in the rat hippocampus. Consequently, AANAT deficiency might be involved in the pathobiology of depression. C57BL/6J mice have a mutant AANAT gene and are considered AANAT-deficient, i.e., "knocked down" (compared with their normal counterparts, C3H/HeJ mice). In this study, we investigated whether AANAT mRNA is expressed in the brain of C57BL/6J and C3H/HeJ mice and whether those mice differ behaviorally, i.e., in a forced swimming test which is used to evaluate antidepressant drugs (such drugs shorten the time of immobility). We found that C3H/HeJ mice express in the brain normal AANAT mRNA, whereas C57BL/6J mice express mutated AANAT mRNA. The mutant, AANAT knocked down C57BL/6J mice displayed significantly longer times of immobility ("depression"). This difference was evident regardless of the circadian rhythm, i.e., both during...Continue Reading

Citations

Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sung-Wuk JangKeqiang Ye
May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Pradoldej SompolKeqiang Ye
Apr 20, 2004·Neuroreport·Tolga UzHari Manev
Jun 16, 2010·The American Journal of Drug and Alcohol Abuse·Arianne S KouroshBryon Adinoff
Jan 23, 2013·Behavioural Brain Research·E B Adamah-BiassiM L Dubocovich
Jan 2, 2007·Medical Hypotheses·Eric Hirsch-RodriguezHari Manev
Mar 7, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Daniel AmblardLaurence Vico
Jun 22, 2005·Journal of Neuroscience Methods·Murat KurtuncuHari Manev
Jul 17, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tolga UzHari Manev
Jun 14, 2018·Neuropsychobiology·Monika Dmitrzak-Weglarz, Edyta Reszka
Nov 5, 2005·Neuroscience and Behavioral Physiology·D F AvgustinovichN N Kudryavtseva
Nov 5, 2005·Neuroscience and Behavioral Physiology·D F Avgustinovich, I L Kovalenko
May 5, 2021·Molecular Biology and Evolution·Daiqing YinGuang Yang

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