Prolonged use of propranolol safely decreases cardiac work in burned children

The Journal of Burn Care & Rehabilitation
P W BaronDavid N Herndon

Abstract

Propranolol has been shown to be effective for as long as 5 days in massively burned children to reduce heart rate and cardiac work. This article describes the use of propranolol given for 10 days to burned children to test whether the drug remains effective and safe in reducing heart rate and cardiac work for longer periods. We prospectively studied 22 children, 1 to 10 years of age with burns covering > or = 40% of their total body surface area. These children were treated with 0.5 to 1.0 mg/kg propranolol given orally or intravenously every 8 hours for 10 days. In both septic and nonseptic patients, propranolol significantly decreased their daily average heart rate (between 10% and 13%, p < 0.05) and rate-pressure product (between 10% and 16%, p < 0.05) compared with their 24-hour mean before propranolol treatment. No significant change in mean arterial blood pressure, or plasma urea nitrogen creatinine or glucose levels could be shown. No hypotension, hypothermia, azotemia, hyperglycemia or hypoglycemia, arrhythmia, bronchospasm, or peripheral ischemia was noted during or after treatment. Whereas propranolol lowered heart rate more per milligram per kilogram body weight when given intravenously, both routes were safe and ef...Continue Reading

Citations

Aug 20, 2005·The International Journal of Biochemistry & Cell Biology·Clifford PereiraDavid N Herndon
Feb 5, 2004·Journal of the American College of Surgeons·Robert L Sheridan, Ronald G Tompkins
Mar 5, 2003·Burns : Journal of the International Society for Burn Injuries·Jean Cassuto, Peter Tarnow
Feb 28, 2001·Journal of the American College of Surgeons·W G Cioffi
Mar 3, 1998·Journal of the American College of Surgeons·C G Ward
Oct 30, 2001·The New England Journal of Medicine·R L Sheridan
Oct 30, 2001·The New England Journal of Medicine·D N HerndonR R Wolfe
Jan 17, 2003·Critical Care Medicine·Robert L Sheridan
Aug 9, 2003·Critical Care Medicine·Jason ShipmanNaji N Abumrad
Dec 24, 2005·Annals of Surgery·Robert E BarrowDavid N Herndon
Aug 13, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Gerd G GauglitzMarc G Jeschke
Dec 9, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Kuzhali MuthuRavi Shankar
Jan 20, 2010·Critical Care Medicine·Ahmed M Al-MousawiDavid N Herndon
Aug 17, 2012·Annals of Surgery·David N HerndonCeleste C Finnerty
Sep 12, 2013·Critical Care : the Official Journal of the Critical Care Forum·Joel WilsonPaul E Wischmeyer
Jul 30, 2009·Critical Care : the Official Journal of the Critical Care Forum·Michael A FlierlKyros R Ipaktchi
Apr 25, 2014·Advances in Wound Care·Samuel P Mandell, Nicole S Gibran
Aug 3, 2014·The Surgical Clinics of North America·Shawn P FaganJeremy Goverman
Nov 6, 2012·Expert Opinion on Pharmacotherapy·Yesenia RojasDavid N Herndon
Jan 6, 2016·International Journal of Molecular Sciences·Ashley N GuilloryCeleste C Finnerty
Dec 5, 2013·Advances in Surgery·Celeste C Finnerty, David N Herndon
Jan 19, 2016·Burns : Journal of the International Society for Burn Injuries·Janine M DukeFiona M Wood
Sep 19, 2012·Burns : Journal of the International Society for Burn Injuries·Marta RosenbergOscar E Suman
May 31, 2011·The Surgical Clinics of North America·Felicia N WilliamsDavid N Herndon
Oct 2, 2009·Clinics in Plastic Surgery·Felicia N WilliamsMarc G Jeschke
Oct 31, 2015·The Journal of Trauma and Acute Care Surgery·Orlando FloresJennifer D Paratz
May 30, 2009·Journal of the American College of Surgeons·Felicia N WilliamsDavid N Herndon
Apr 21, 2009·Surgery·Xiao-Jun ZhangDavid N Herndon
Mar 24, 2007·The Veterinary Clinics of North America. Equine Practice·Peggy S Marsh
May 20, 1998·Current Problems in Pediatrics·R L Sheridan
Feb 3, 2005·Burns : Journal of the International Society for Burn Injuries·Jean CassutoJohanna Räntfors
Feb 28, 2006·Journal of the American College of Surgeons·Clifford T PereiraDavid N Herndon
Oct 28, 2005·Advances in Surgery·Clifford T Pereira, David N Herndon
Sep 25, 2001·Current Problems in Surgery·R L Sheridan
Jun 19, 2012·The Journal of Surgical Research·Robert KraftMarc G Jeschke
Oct 23, 2012·The Journal of Pediatrics·Laura J PorroOscar E Suman
Oct 12, 2014·Medicina intensiva·T Núñez-VillaveiránA García-de-Lorenzo
Aug 31, 2016·Burns : Journal of the International Society for Burn Injuries·Michael Thomas LeCompteSteven Alexander Kahn
Jun 9, 2004·Lancet·David N Herndon, Ronald G Tompkins
Aug 19, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·Michael M ChenElizabeth J Kovacs
Sep 18, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Celeste C FinnertyDavid N Herndon
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sharon L CushingJonathan A Perkins
Dec 4, 2008·Plastic and Reconstructive Surgery·Bruna Romana-SouzaAndréa Monte-Alto-Costa
Feb 28, 2017·Journal of Burn Care & Research : Official Publication of the American Burn Association·Ashley N GuilloryCeleste C Finnerty
May 15, 2018·Journal of Burn Care & Research : Official Publication of the American Burn Association·Sylvia OjedaWalter J Meyer
Jul 19, 2011·Journal of Intensive Care Medicine·Kevin R KastenRichard J Kagan

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