Prolonged viral shedding in a lymphoma patient with COVID-19 infection receiving convalescent plasma

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Ayşe KarataşHakan Göker

Abstract

Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first identified in Wuhan, China; and spread all over the world. Reverse-transcription polymerase chain reaction (RT-PCR) test for SARS-CoV-2 usually returns to negative in 20 days post-infection, but prolonged positivity has been reported up to 63 days. A case whose viral shedding lasted 60 days is reported from China. Herein we report a patient with a history of autologous stem cell transplantation (ASCT) for lymphoma whose RT-PCR test remained positive for SARS-CoV-2 for 74 days. The prolonged RT-PCR positivity, despite convalescent plasma infusion, may suggest that the given antibodies may be ineffective in terms of viral clearance. In patients with hematological malignancies or immunosuppression, such as ASCT, may lead to prolonged viral shedding, and strict isolation is warranted for long-term SARS-CoV-2 infection control.

Citations

Oct 13, 2020·The Cochrane Database of Systematic Reviews·Khai Li ChaiNicole Skoetz
Feb 2, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Daniele Focosi, Massimo Franchini
Feb 19, 2021·BMC Infectious Diseases·Luna ColagrossiCarlo Federico Perno
Feb 26, 2021·SAGE Open Medical Case Reports·Sm Rashed Ul IslamSaif Ullah Munshi
Mar 21, 2021·Enfermedades infecciosas y microbiología clínica·Marcial Delgado-FernándezJuan Diego Ruíz-Mesa
Mar 27, 2021·Clinical Case Reports·Marthilde BrzyckiThomas R Chauncey
Apr 8, 2021·JMIR Public Health and Surveillance·Henry T PengAndrew Beckett
Apr 30, 2021·The Lancet. HIV·Juan AmbrosioniUNKNOWN COVID-19 in HIV Investigators
May 21, 2021·The Cochrane Database of Systematic Reviews·Vanessa PiechottaNicole Skoetz
May 27, 2021·Transfusion·Jonathon W SenefeldMichael J Joyner
Jun 15, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Guido LeviMichela Bezzi
Jun 24, 2021·Curēus·Roopam JariwalRalph Garcia-Pacheco
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Methods Mentioned

BETA
ICE
Blood Collection
ELISA
PCR

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