Prolonging herd immunity to cholera via vaccination: Accounting for human mobility and waning vaccine effects

PLoS Neglected Tropical Diseases
Corey M PeakCaroline O Buckee

Abstract

Oral cholera vaccination is an approach to preventing outbreaks in at-risk settings and controlling cholera in endemic settings. However, vaccine-derived herd immunity may be short-lived due to interactions between human mobility and imperfect or waning vaccine efficacy. As the supply and utilization of oral cholera vaccines grows, critical questions related to herd immunity are emerging, including: who should be targeted; when should revaccination be performed; and why have cholera outbreaks occurred in recently vaccinated populations? We use mathematical models to simulate routine and mass oral cholera vaccination in populations with varying degrees of migration, transmission intensity, and vaccine coverage. We show that migration and waning vaccine efficacy strongly influence the duration of herd immunity while birth and death rates have relatively minimal impacts. As compared to either periodic mass vaccination or routine vaccination alone, a community could be protected longer by a blended "Mass and Maintain" strategy. We show that vaccination may be best targeted at populations with intermediate degrees of mobility as compared to communities with very high or very low population turnover. Using a case study of an internal...Continue Reading

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Oct 2, 2020·Nature Communications·Kyra H GrantzAmy Wesolowski
Apr 4, 2021·Tropical Medicine and Infectious Disease·Jacqueline Deen, John D Clemens
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