Prominent corneal nerves in patients with multiple endocrine neoplasia type 2A: diagnostic implications

World Journal of Surgery
S TakaiT Kobayashi

Abstract

We examined corneal nerves of 22 patients from 10 families with multiple endocrine neoplasia type 2A (MEN-2A). According to the findings in slit-lamp biomicroscopic examination and photographic documentation, the increased visibility of corneal nerves were classified into 5 grades (Grade 0 = invisible to Grade 4 = as thick as in MEN-2B). All eyes of normal subjects, 19 of 20 eyes of patients with anterior keratoconus, and 11 of 12 eyes of patients with non-hereditary medullary thyroid carcinoma (MTC) were either grade 0 or 1, and the remaining 2 eyes were evaluated as grade 2. Of the 44 eyes of MEN-2A patients, 5 (11.4%) eyes were grade 0, 11 (25%) eyes were grade 1, 19 (43.2%) eyes were grade 2, 8 (18.2%) eyes were grade 3, and 1 (2.3%) eye was grade 4. Thus, more than 60% of eyes of MEN-2A patients showed pathologically thickened corneal nerves of varying degree (grade 2 or higher). There was no definite relationship between the grade of corneal nerve thickening and the patient's age or presence of pheochromocytoma. Differences in the grade of corneal nerve thickening were observed among affected members belonging to the same MEN-2A family, but unaffected members of the family never showed prominent corneal nerves of grade 2 ...Continue Reading

References

Mar 15, 1991·American Journal of Ophthalmology·S KinoshitaS Takai
Feb 1, 1981·American Journal of Ophthalmology·B SpectorS A Wells

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Citations

Sep 1, 1993·Seminars in Surgical Oncology·J L Pasieka
Oct 1, 2008·International Journal of Biomedical Imaging·Jean J ChenG Bruce Pike
Feb 21, 2016·Archivos de la Sociedad Española de Oftalmología·C SevillanoF J Cores
Sep 7, 2016·International Journal of Endocrine Oncology·Diala El-MaoucheStephen J Marx
Jan 28, 2014·Survey of Ophthalmology·Brittany Simmons ShaheenSandeep Jain
Feb 24, 2001·International Ophthalmology Clinics·S K Kim, C H Dohlman
Nov 12, 2020·Journal français d'ophtalmologie·R CuyaubèreN Bouheraoua

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