PMID: 11900293Mar 20, 2002Paper

Prominent I(Ks) in epicardium and endocardium contributes to development of transmural dispersion of repolarization but protects against development of early afterdepolarizations

Journal of Cardiovascular Electrophysiology
Alexander Burashnikov, Charles Antzelevitch

Abstract

Previous studies from our laboratory demonstrated (1) a much larger I(Ks) and (2) inability to induce early afterdepolarization (EAD) activity in epicardial and endocardial cells versus M cells. This study tests the hypothesis that these two characteristics are interrelated. Standard and floating microelectrode techniques were used to record transmembrane activity from the canine left ventricular epicardial, M, and endocardial regions in isolated tissue slices and arterially perfused wedge preparations. The I(Kr) blocker E-4031 (1 to 10 microM) caused prominent prolongation of action potential duration (APD) and induced EADs in tissues isolated from the M region, but not those from epicardium or endocardium, causing a large transmural dispersion of APD. In contrast, the I(Ks) blocker chromanol 293B (10 to 30 microM) produced moderate prolongation of APD without EADs in all three tissue types. The combination of E-4031 (1 microM) and chromanol 293B (30 microM) resulted in profound prolongation of APD and the development of EADs in all three tissue types. In the perfused wedge, neither E-4031 nor chromanol 293B alone could induce EADs. In combination, the two drugs caused significant prolongation of APD and EADs in all three tran...Continue Reading

Citations

Oct 31, 2012·Cardiovascular Drugs and Therapy·Alexander Burashnikov, Charles Antzelevitch
May 9, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi AibaKenji Sunagawa
Nov 26, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Ryo HaraguchiKazuo Nakazawa
Apr 24, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hsiang-Chun LeeJianmin Cui
Aug 27, 2011·Pharmacology & Therapeutics·Alexander Burashnikov, Charles Antzelevitch
Jan 13, 2011·Journal of Pharmacological and Toxicological Methods·Pascal ChamperouxJean-Yves Le Guennec
Jul 12, 2008·Pharmacology & Therapeutics·Jules C HancoxYi Hong Zhang
Jul 15, 2004·Journal of Cardiovascular Electrophysiology·Salim F Idriss, Patrick D Wolf
Feb 9, 2007·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Norbert JostAndrás Varró
Apr 12, 2006·Pacing and Clinical Electrophysiology : PACE·Alexander Burashnikov, Charles Antzelevitch
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Norihiro UedaJiashin Wu
Jan 18, 2005·Journal of the American College of Cardiology·Takeshi AibaKenji Sunagawa
May 19, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Alexander BurashnikovCharles Antzelevitch
Aug 25, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Rodrigo Weber dos SantosWayne R Giles
Apr 3, 2014·Physiological Reviews·Nicole SchmittSøren-Peter Olesen
Sep 1, 2020·Journal of the American Heart Association·Tyler ShuggBrian R Overholser
Jan 19, 2011·Fundamental & Clinical Pharmacology·Paolo Emilio PudduJoffrey Ducroq
Aug 2, 2003·Journal of Veterinary Internal Medicine·Melissa R FinleyLisa C Freeman
Mar 18, 2011·British Journal of Pharmacology·L VirágA Varró

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