Prominently decreased hippocampal neurogenesis in a spontaneous model of type 1 diabetes, the nonobese diabetic mouse

Experimental Neurology
Juan BeauquisAlejandro F De Nicola

Abstract

In human diabetes, degenerative and functional disorders of the central nervous system, including depression, are common findings. Defective dentate gyrus (DG) neurogenesis is associated with affective-related disorders and depression. We previously demonstrated reduced DG neurogenesis in a pharmacological type 1 diabetes model, the streptozotocin (STZ)-treated mouse. Here, we explored DG neurogenesis in a spontaneous T1D model, the nonobese diabetic (NOD) mouse, at prediabetic and diabetic stages. Cell proliferation was assessed in the DG of 5, 8 and 12-week-old control C57BL/6 and BALB/c strains and NOD mice, killed 2 h after bromodeoxyuridine (BrdU) administration. Survival of the newly generated cells was studied in 15-week-old animals that were killed 21 days after BrdU injection. The number of proliferative BrdU-positive cells in the DG was, regardless of age, constantly and significantly lower in NOD than in control strains, showing the presence of hippocampal alterations far before clinical diabetes onset in NOD mice. Diabetes also strongly decreased cell survival in NOD DG. However, cell phenotype proportion, as assessed by co-localization with neuronal or glial markers and confocal microscopy, was not modified. Hippoc...Continue Reading

References

May 1, 1992·Diabetes·A L McCall
Mar 1, 1991·Neurobiology of Aging·J R GossD G Morgan
Jun 1, 1965·The Journal of Comparative Neurology·J Altman, G D Das
Jul 1, 1993·Neurobiology of Aging·M J West
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·G KempermannF H Gage
Apr 30, 1998·Neurobiology of Aging·L G Sheffield, N E Berman
Aug 26, 1998·Journal of Neurobiology·H A CameronR D McKay
Dec 22, 1999·Neurology·A OttM M Breteler
Dec 22, 1999·Brain, Behavior, and Immunity· BluthF Homo-Delarche
Oct 12, 2000·Neuroscience Letters·J Jackson-GuilfordL K Nisenbaum
Nov 14, 2000·Trends in Neurosciences·W H Gispen, G J Biessels
May 26, 2001·Diabetes Care·R J AndersonP J Lustman
Aug 17, 2001·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M MoritaY Notsu
Mar 23, 2002·Journal of Neurochemistry·F GardoniM Di Luca
Apr 12, 2002·Brain Research. Developmental Brain Research·N L Hayes, R S Nowakowski
Jul 16, 2003·The European Journal of Neuroscience·J L Bizon, M Gallagher
Nov 15, 2003·Science·Michelle L MonjeTheo D Palmer
Dec 19, 2003·Pediatric Research·Kelvin A YamadaDaniel G Herrera
Jul 24, 2004·Trends in Neurosciences·Gerd KempermannGolo Kronenberg
Mar 8, 2005·Brain Research·Yanina RevsinAlejandro F De Nicola
Mar 25, 2005·Physiological Reviews·Djoher Nora AbrousMichel Le Moal
Jul 19, 2005·Annual Review of Neuroscience·Guo-li Ming, Hongjun Song
Aug 9, 2005·Brain Research. Developmental Brain Research·Karin S HougaardSøren P Lund
Oct 15, 2005·Neurobiology of Aging·Geert Jan Biessels, Willem Hendrik Gispen
Jan 18, 2006·Hippocampus·Christian Mirescu, Elizabeth Gould
Jun 30, 2006·Cellular and Molecular Neurobiology·Flavia E SaraviaAlejandro F De Nicola
Nov 23, 2006·Current Diabetes Reports·Dinesh Selvarajah, Solomon Tesfaye
Apr 27, 2007·Psychoneuroendocrinology·Flavia SaraviaAlejandro F De Nicola

❮ Previous
Next ❯

Citations

Jun 9, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shao-hua WangBing-quan Yang
Aug 13, 2010·The Review of Diabetic Studies : RDS·Josiane CoulaudFrancoise Homo-Delarche
Mar 5, 2011·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·P BaratV Vautier
Sep 13, 2011·Neurochemical Research·Raquel Alvarez-NöltingFrancisco J Romero
May 9, 2009·Hormones and Behavior·Marzia PesaresiRoberto Cosimo Melcangi
Jan 14, 2009·Brain Research·Bradley T LangRaghu Vemuganti
Jan 6, 2009·Journal of Pharmacological and Toxicological Methods·Darrick T BaluIrwin Lucki
Dec 2, 2008·Behavioural Brain Research·Edgardo O AlvarezFlavia Saravia
Oct 2, 2015·Aging and Disease·João M N Duarte
May 18, 2013·Neuroscience and Biobehavioral Reviews·Nancy HoIrwin Lucki
Apr 17, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Luciana PietraneraAlejandro F De Nicola
Jun 16, 2015·BioMed Research International·Shin FujimakiTomoko Kuwabara
Aug 28, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Nelli GiribabuNaguib Salleh
May 14, 2016·Brain Research·Wilma Helena OliveiraChristina Alves Peixoto
Jul 2, 2016·International Journal of Biological Macromolecules·Mei LiuXiguang Qi
Dec 6, 2012·Stem Cells International·Tomás P Bachor, Angela M Suburo
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kristen L ZuloagaNabil J Alkayed
Oct 19, 2017·International Journal of Molecular Sciences·Shin Fujimaki, Tomoko Kuwabara
Feb 25, 2009·Annals of the New York Academy of Sciences·Juan BeauquisFlavia Saravia
Mar 27, 2012·The Journal of Veterinary Medical Science·Sung Min NamYeo Sung Yoon
Feb 19, 2020·Journal of Neurochemistry·Carmen Hierro-BujalanceMonica Garcia-Alloza
Feb 20, 2015·Metabolic Brain Disease·Tomás P BachorAngela M Suburo
Jan 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ali HeidarianpourNaser Mirazi
Jan 1, 2021·International Journal of Molecular Sciences·Thomas Ho-Yin Lee, Suk-Yu Yau

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.