Promiscuous recognition of major histocompatibility complex class II determinants in cyclosporine-induced syngeneic graft-versus-host disease: specificity of cytolytic effector T cells

Transplantation
A HessL Horwitz

Abstract

Administration of the immunosuppressive drug cyclosporine after syngeneic/autologous bone marrow transplantation paradoxically elicits a systemic autoimmune syndrome resembling graft-versus-host disease (GVHD). This syndrome, termed autologous or syngeneic GVHD, is associated with the development of a highly restricted repertoire of cytolytic T lymphocytes that promiscuously recognizes major histocompatibility complex class II determinants, including self. Vbeta8.5+CD8+ effector lymphocytes and T-cell clones were isolated from Lewis rats with cylosporine-induced syngeneic GVHD. The specificity of the effector T cells and T-cell clones was examined in vitro. The pathogenicity of the T-cell clones was confirmed in vivo using a local graft-versus-host reaction assay. Clonal analysis reveals that the pathogenic effector T cells recognize a peptide from the invariant chain termed CLIP in association with major histocompatibility complex class II determinants. Moreover, there appears to be an additional interaction between the N-terminal flanking region of CLIP and the Vbeta segment of the T cell receptor. The results suggest that recognition of this highly conserved peptide along with the additional interaction between the flanking ...Continue Reading

References

Dec 15, 1991·Journal of Immunological Methods·P Matzinger
Jan 1, 1985·Annual Review of Immunology·E M Shevach
Feb 1, 1982·Clinical Immunology and Immunopathology·W E BeschornerG W Santos
Jan 1, 1994·Annual Review of Immunology·P Cresswell
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Beeson, H M McConnell
Jul 1, 1993·The Journal of Experimental Medicine·R M ChiczJ L Strominger

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Citations

Mar 27, 2001·Transplantation Proceedings·A HessL Horwitz
Mar 20, 1999·Transplantation Proceedings·C ThoburnA Hess
Feb 22, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Allan D HessEmilie C Bright
Jun 21, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·W ChenA D Hess
Apr 6, 2005·Transplantation Proceedings·Y MiuraA D Hess
Mar 3, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yuji MiuraAllan D Hess
Apr 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Allan D Hess, Christopher J Thoburn
Aug 21, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Christopher J ThoburnAllan D Hess
Oct 3, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·A D HessE Van der Wall
Jan 10, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Allan D Hess
Mar 29, 2003·Blood·Takanori TeshimaJames L M Ferrara
Nov 26, 2002·Hematology·David G MaloneyJudith A Shizuru
Feb 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·J Anthony BrandonJ Scott Bryson
Feb 20, 2003·International Journal of Immunopathology and Pharmacology·J. G.m.c. Damoiseaux
Sep 28, 2002·Transplantation·Shaun M KunisakiDavid H Sachs
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·J Scott BrysonAlan M Kaplan

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