Promise and Implementation of Proteomic Prostate Cancer Biomarkers

Diagnostics
Agnieszka LatosinskaHarald Mischak

Abstract

Prostate cancer is one of the most commonly diagnosed malignancy and the fifth leading cause of cancer mortality in men. Despite the broad use of prostate-specific antigen test that resulted in an increase in number of diagnosed cases, disease management needs to be improved. Proteomic biomarkers alone and or in combination with clinical and pathological risk calculators are expected to improve on decreasing the unnecessary biopsies, stratify low risk patients, and predict response to treatment. To this end, significant efforts have been undertaken to identify novel biomarkers that can accurately discriminate between indolent and aggressive cancer forms and indicate those men at high risk for developing prostate cancer that require immediate treatment. In the era of "big data" and "personalized medicine" proteomics-based biomarkers hold great promise to provide clinically applicable tools, as proteins regulate all biological functions, and integrate genomic information with the environmental impact. In this review article, we aim to provide a critical assessment of the current proteomics-based biomarkers for prostate cancer and their actual clinical applicability. For that purpose, a systematic review of the literature publishe...Continue Reading

Citations

Oct 3, 2019·Expert Review of Molecular Diagnostics·Emmy BoerrigterJack A Schalken

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Methods Mentioned

BETA
biopsies
biopsy
electrophoresis
Enzyme-linked immunosorbent assay
ELISA
GTPase

Software Mentioned

Prostarix
Ingenuity
OncotypeDX
Decipher
of Science
ProMark
Prolaris
Web

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