Promise of vitamin D analogues in the treatment of hyperproliferative conditions

Molecular Cancer Therapeutics
Sonoko Masuda, Glenville Jones

Abstract

1Alpha,25-dihydroxyvitamin D3 [1alpha,25-(OH)2D3; calcitriol] is best known as a hormone involved in calcium homeostasis but is also a potent antiproliferative agent in many cell types, particularly epithelial cells. 1Alpha,25(OH)2D3 mediates its actions through a classic steroid hormone-like transcriptional mechanism by influencing the expression of hundreds of genes. Effects of 1alpha,25(OH)2D3 have been observed on expression of cell cycle regulators, growth factors and their receptors, apoptotic machinery, metastatic potential, and angiogenesis; all of which have some effect on hyperproliferative conditions. This minireview focuses on the anticancer potential of 1alpha,25(OH)2D3 and its analogues by summarizing the promising data from animal and human trials of 1alpha,25(OH)2D3 and some of the more interesting synthetic vitamin D analogues in the treatment of a variety of different animal cancer models and in human patients with advanced cancer. Optimal administration of vitamin D analogues is only just being achieved with high-dose intermittent administration overcoming bioavailability and hypercalcemia problems and combination therapy with cytotoxic agents (taxols and cisplatins), antiresorptive agents (bisphosphonates), ...Continue Reading

References

Jan 1, 1986·Annals of the New York Academy of Sciences·J S AdamsO P Sharma
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E AbeT Suda
Oct 23, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R St-ArnaudF H Glorieux
May 23, 1998·FEBS Letters·J M González-SanchoA Muñoz
Oct 28, 1998·Physiological Reviews·G JonesH F DeLuca
Jan 23, 1999·The Journal of Clinical Investigation·F F SafadiN E Cooke
May 18, 1999·Breast Cancer Research and Treatment·K KoshizukaH P Koeffler
Aug 6, 2000·Circulation Research·D J MantellA E Canfield
Oct 12, 2000·Molecular and Cellular Endocrinology·V Sung, D Feldman
May 8, 2001·Journal of Gastroenterology and Hepatology·I G FinlayD L Morris
Jul 27, 2001·Journal of Cellular Physiology·L YangM G Brattain
Jun 20, 2002·The Journal of Biological Chemistry·Ida Stenfeldt MathiasenMarja Jäättelä
Dec 18, 2002·Annals of the New York Academy of Sciences·Hesso Farhan, Heide S Cross
Dec 24, 2002·Clinical Pharmacology and Therapeutics·Josephia R MuindiDonald L Trump
Jun 7, 2003·American Journal of Physiology. Endocrinology and Metabolism·L Darryl Quarles
Jun 12, 2003·International Journal of Cancer. Journal International Du Cancer·Gregory E WeitsmanRuth Koren
Jul 4, 2003·The Journal of Nutrition·Donna M PeehlDavid Feldman
Sep 25, 2003·Breast Cancer Research and Treatment·K W ColstonL Binderup

❮ Previous
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Citations

Oct 22, 2009·Biogerontology·Daniel P Hayes
May 31, 2013·Journal of Cardiovascular Translational Research·Oksan Gezmish, Mary Jane Black
Jul 11, 2008·The American Journal of Clinical Nutrition·Marian L NeuhouserRachel Ballard-Barbash
Jun 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Luz E Tavera-MendozaJohn H White
Feb 26, 2011·Omics : a Journal of Integrative Biology·Paola MutiSabrina Strano
Jun 27, 2008·Transplantation·Didier DuclouxJean-Marc Chalopin
Jun 18, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Edith K Y TangRobert C Tuckey
Aug 13, 2008·Endocrine Reviews·Roger BouillonMarie Demay
Jul 14, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David A HanleyUNKNOWN Guidelines Committee of the Scientific Advisory Council of Osteoporosis Canada
Jul 14, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David A HanleyUNKNOWN Guidelines Committee of the Scientific Advisory Council of Osteoporosis Canada
Jun 23, 2011·Journal of Molecular Endocrinology·Eiji MunetsunaToshiyuki Sakaki
Jul 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·David E ProsserGlenville Jones
Oct 12, 2013·Antioxidants & Redox Signaling·Mary A NdiayeNihal Ahmad
Oct 13, 2010·Annual Review of Pharmacology and Toxicology·Aruna V Krishnan, David Feldman
Apr 9, 2011·BMC Biotechnology·Nicklas H StaunstrupJacob Giehm Mikkelsen
Dec 5, 2008·Nutrition Reviews·Sam Samuel, Michael D Sitrin
Mar 5, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Edith K Y TangRobert C Tuckey
Apr 25, 2012·Rheumatic Diseases Clinics of North America·Glenville Jones
Apr 19, 2013·Revista española de cirugía ortopédica y traumatología·M Mesa-RamosP Carpintero-Benítez
Jan 3, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Elaine W TieuRobert C Tuckey
Sep 25, 2010·Placenta·J S ShinD M Nelson
Jun 1, 2010·Endocrinology and Metabolism Clinics of North America·Glenville Jones
Jul 14, 2010·Biochimica Et Biophysica Acta·Inge Schuster
Mar 9, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Bo-Ying BaoYi-Fen Lee
Dec 8, 2009·Journal of Molecular Biology·Andrew J AnnaloraC David Stout
Oct 16, 2008·Regulatory Toxicology and Pharmacology : RTP·Enrico BaroniDaniele D'Ambrosio
Jun 27, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ian H de BoerNoel S Weiss
Jan 24, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Mohamed Sayed GomaaAndrea Brancale
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Kåre EdvardsenEiliv Lund
Feb 23, 2011·Biopharmaceutics & Drug Disposition·Han-Joo MaengK Sandy Pang
Aug 5, 2010·Archives of Medical Research·Tomasz StepienHenryk Stepien

❮ Previous
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