Promise versus reality: optimism bias in package inserts for tuberculosis diagnostics.

Journal of Clinical Microbiology
Claudia M DenkingerMadhukar Pai

Abstract

Laboratorians and clinicians often rely on package inserts of diagnostic tests to assess their accuracy. We compared test accuracy for tuberculosis diagnostics reported in 19 package inserts against estimates in published meta-analyses and found that package inserts generally report overoptimistic accuracy estimates. However, package inserts of most tests approved by the U.S. Food and Drug Administration (FDA) or endorsed by the World Health Organization provide more realistic estimates that agree with meta-analyses.

References

Jan 22, 2003·JAMA : the Journal of the American Medical Association·Justin E BekelmanCary P Gross
Jun 18, 2005·Clinical Chemistry·Anne W S RutjesPatrick M M Bossuyt
Feb 3, 2007·Health Technology Assessment : HTA·J DinnesA Lalvani
Jan 16, 2009·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN Centers for Disease Control and Prevention (CDC)
May 22, 2009·BMC Infectious Diseases·Freddie BwangaMoses L Joloba
Mar 13, 2010·Current Opinion in Pulmonary Medicine·Madhukar PaiAndrew Ramsay
Jun 15, 2010·The Journal of Antimicrobial Chemotherapy·Kwok Chiu ChangRaphael Chiu Yeung Chan
Jan 18, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Adithya CattamanchiMadhukar Pai
Jun 28, 2011·The European Respiratory Journal·J MinionD Menzies
Jul 16, 2011·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·N StallP Daley
Aug 13, 2011·Clinical and Vaccine Immunology : CVI·L L FloresS Laal
Oct 12, 2011·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·E LeungD Menzies
Dec 27, 2011·The Indian Journal of Medical Research·Sarman Singh, V M Katoch
Feb 3, 2012·The European Respiratory Journal·J GrenierM Pai
Apr 6, 2012·The Journal of Infectious Diseases·Frank CobelensUNKNOWN Evidence for Scale-up Group
Apr 2, 2013·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·Q GuoZ-Y Hu

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Citations

Jan 5, 2014·BMC Infectious Diseases·Jacob CreswellLucica Ditiu
Mar 15, 2015·The Journal of Infectious Diseases·Claudia M DenkingerMark D Perkins
Jul 28, 2017·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Sebastian KrinnerJean-Philippe Brantut
Mar 30, 2017·Proceedings of the National Academy of Sciences of the United States of America·Chang LiuYe Hu

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