Promising Alternative Therapeutics for Oral Candidiasis

Current Medicinal Chemistry
Célia F RodriguesMariana C R Henriques

Abstract

Candida is the main human fungal pathogen causing infections (candidiasis), mostly in the elderly and immunocompromised hosts. Even though Candida spp. is a member of the oral microbiota in symbiosis, in some circumstances, it can cause microbial imbalance leading to dysbiosis, resulting in oral diseases. Alternative therapies are urgently needed to treat oral candidiasis (usually associated to biofilms), as several antifungal drugs' activity has been compromised. This has occurred especially due to an increasing occurrence of drugresistant in Candida spp. strains. The overuse of antifungal medications, systemic toxicity, cross-reactivity with other drugs and a presently low number of drug molecules with antifungal activity, have contributed to important clinical limitations. We undertook a structured search of bibliographic databases (PubMed Central, Elsevier's ScienceDirect, SCOPUS and Springer's SpringerLink) for peer-reviewed research literature using a focused review in the areas of alternatives to manage oral candidiasis. The keywords used were "candidiasis", "oral candidiasis", "biofilm + candida", "alternative treatment", "combination therapy + candida" and the reports from the last 10 to 15 years were considered for th...Continue Reading

References

Jan 1, 1976·Acta Odontologica Scandinavica·M LarmasA Scheinin
May 1, 1989·The Journal of Applied Bacteriology·R Fuller
Dec 1, 1988·Antimicrobial Agents and Chemotherapy·T L TalaricoW J Dobrogosz
Nov 1, 1972·Infection and Immunity·J Van HouteA J Pulkkinen
Sep 1, 1982·Applied and Environmental Microbiology·J M Jay
Jun 1, 1995·The Journal of Nutrition·G R Gibson, M B Roberfroid
Sep 1, 1995·Antimicrobial Agents and Chemotherapy·S P Hawser, L J Douglas
Oct 9, 1999·Clinical Microbiology Reviews·M M Cowan
Mar 29, 2000·Journal of Applied Microbiology·H J Dorman, S G Deans
Sep 30, 2000·Applied and Environmental Microbiology·M G GänzleW P Hammes
May 17, 2002·The Journal of Hospital Infection·V Krcmery, A J Barnes
Aug 16, 2005·Archives of Medical Research·Patricia E LusbyJenny M Wilkinson
Jan 18, 2006·Journal of Photochemistry and Photobiology. B, Biology·Sandra Cristina de SouzaAntonio Olavo Cardoso Jorge
May 17, 2006·Medical Mycology·Julie IrishShona E Blair
Dec 1, 2006·BMC Complementary and Alternative Medicine·Seenivasan PrabuseenivasanSavarimuthu Ignacimuthu
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Dec 25, 2007·Lasers in Medical Science·Ligia Maria GiroldoMaricilia Silva Costa
Jan 10, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mary Ellen Sanders
Feb 19, 2008·Oral Microbiology and Immunology·P KõllL Hammarström
Sep 24, 2008·Journal of Clinical Nursing·Joy BardyAlexander Molassiotis
Oct 23, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Letícia EstevinhoErmelinda Pereira
Nov 19, 2008·Journal of Photochemistry and Photobiology. B, Biology·Betânia Maria SoaresPatrícia Silva Cisalpino
Mar 24, 2009·The Journal of Hospital Infection·L N MirandaA S Levin
May 16, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L HornKaren M Webster
Oct 31, 2009·Ageing Research Reviews·Kirsti TiihonenNina Rautonen
Jan 12, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Ewerton Garcia de Oliveira MimaVanderlei Salvador Bagnato
Nov 30, 2010·Nature Reviews. Microbiology·Gregor ReidHenk J Busscher
Dec 8, 2010·Periodontology 2000·David W WilliamsMichael A O Lewis
Jan 15, 2011·Journal of Leukocyte Biology·Pascal GourbeyreMarie Bodinier
Feb 12, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Gordon RamageJeremy Bagg
Mar 18, 2011·Trends in Microbiology·Sónia SilvaJoana Azeredo

❮ Previous
Next ❯

Citations

Aug 28, 2019·Current Medicinal Chemistry·Mariana Henriques, Célia F Rodrigues
Aug 28, 2020·Frontiers in Cellular and Infection Microbiology·Rodnei Dennis RossoniEleftherios Mylonakis
Sep 2, 2020·Medicina·Javad Sharifi-RadDaniela Calina
Feb 24, 2021·Disease-a-month : DM·Shailesh GondivkarKamran Habib Awan
May 25, 2021·Critical Reviews in Food Science and Nutrition·José Carlos AndradeCélia F Rodrigues
Jan 15, 2022·Clinical Oral Investigations·Juliana Silva RibeiroMarco Cícero Bottino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

© 2022 Meta ULC. All rights reserved