Promising Antifungal Targets Against Candida albicans Based on Ion Homeostasis

Frontiers in Cellular and Infection Microbiology
Yiman LiShujuan Sun

Abstract

In recent decades, invasive fungal infections have been increasing significantly, contributing to high incidences and mortality in immunosuppressed patients. Candida albicans (C. albicans) is the most prevalent opportunistic fungal pathogen in humans that can cause severe and often fatal bloodstream infections. Current antifungal agents have several limitations, including that only a small number of classes of antifungals are available, certain of which have severe toxicity and high cost. Moreover, the emergence of drug resistance is a new limitation to successful patient outcomes. Therefore, the development of antifungals with novel targets is an essential strategy for the efficient management of C. albicans infections. It is widely recognized that ion homeostasis is crucial for all living cells. Many studies have identified that ion-signaling and transduction networks are central to fungal survival by regulating gene expression, morphological transition, host invasion, stress response, and drug resistance. Dysregulation of ion homeostasis rapidly mediates cell death, forming the mechanistic basis of a growing number of compounds that elicit antifungal activity. Most of the potent antifungals have been widely used in the clini...Continue Reading

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Citations

Jan 29, 2019·Frontiers in Microbiology·Andrzej GórskiBeata Weber-Dąbrowska
Jan 11, 2020·Frontiers in Cellular and Infection Microbiology·Rafael Wesley BastosGustavo H Goldman
Jul 26, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anca ToiuIlioara Oniga
Jul 30, 2020·Journal of Fungi·Leandro B R Da SilvaJoshua D Nosanchuk
Jun 14, 2019·Frontiers in Cellular and Infection Microbiology·Claudia Simm, Robin C May
Feb 16, 2021·Critical Reviews in Microbiology·Hui LuYuanying Jiang
Feb 18, 2021·FEMS Microbiology Reviews·Wouter Van GenechtenLiesbeth Demuyser
May 1, 2021·Biomolecules·Marina VolkovaAlbert Guskov
May 15, 2021·Microbiological Research·Wanqian LiYuanying Jiang

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Methods Mentioned

BETA
protein folding

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