Promising biocidal activity of thymol loaded chitosan silver nanoparticles (T-C@AgNPs) as anti-infective agents against perilous pathogens

International Journal of Biological Macromolecules
H M ManukumarH N Naveen Kumar

Abstract

The advent of biodegradable polymer-encapsulated drug nanoparticles has made an exciting area of drug delivery research. The present study investigated novel and simple route for synthesis of thymol loaded chitosan silver nanoparticles (T-C@AgNPs) using chitosan and thymol as reducing, capping agent respectively to understand the therapeutic efficacy. The UV-vis spectroscopy, DLS, FT-IR, SEM, EDS, XRD used for characterization and radical scavenging activity, anti-microbial and biocompatibility was taken to ascertain an efficacy of novel T-C@AgNPs. The T-C@AgNPs intense peak at 490nm indicates the formation of nanoparticles and had average particle size of 28.94nm with spherical shape, monodisperse state in water, also exhibited excellent biocompatibility of cubic shaped pure silver element containing T-C@AgNPs. The antibacterial activity was studied for gram positive and gram negative food-borne pathogens and effective inhibition at 100μgmL-1to S. aureus, S. epidermidis, S. haemolyticus (10.08, 10.00, 11.23mm) and S. typhimurium, P. aeruginosa and S. flexneri (9.28, 9.33, 12.03mm) compared to antibiotic Streptomycin. This study revealed the efficacy against multiple food-borne pathogens and therapeutic efficacy of T-C@AgNPs of...Continue Reading

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Citations

Dec 13, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Prateek MathurN K Jain
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta Chylińska, Halina Kaczmarek
Nov 6, 2018·International Journal of Biological Macromolecules·Swaminathan JijiKrishna Kadirvelu
Aug 10, 2021·Frontiers in Bioengineering and Biotechnology·Gloria María Pontes-QueroBlanca Vázquez-Lasa

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